trimethoprim cas no:738-70-5
Synonyms: trimethoprim crystalline; 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyldiamine; TMP; Antibiotic synergist
Nametrimethoprim
CAS738-70-5
Synonymstrimethoprim crystalline; 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyldiamine; TMP; Antibiotic synergist
EINECS(EC#)212-006-2
Molecular FormulaC14H18N4O3
Molecular Weight290.32
Appearancewhite to yellowish powder
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard T: Toxic;
Risk R25
Safety
Hazard Codes:?
T
Risk Statements: 25?
R25: Toxic if swallowed
Safety Statements: 45?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 3249
WGK Germany: 3
RTECS: UV8225000
F: 8-10-21?
F 8: Photosensitive
F 10: Keep under argon
F 21: Sensitive to humidity
HazardClass: 6.1(b)
PackingGroup: III?
Use of 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine (CAS NO.738-70-5) is contraindicated during pregnancy, especially the first trimester, and for sufferers of certain blood disorders. It is contraindicated?to use trimethoprim during pregnancy, especially the first trimester, and for sufferers of certain blood disorders. 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine (CAS NO.738-70-5) also?may be involved in a reaction similar to disulfiram when alcohol is consumed after it is used, particularly when used in combination with sulfamethoxazole .It can also reduce clearance of creatinine at renal tubules.
HS Code 29335995
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LDLo |
intravenous |
90mg/kg (90mg/kg) |
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
Chemotherapy Vol. 14, Pg. 37, 1969.
? |
| mouse |
LD50 |
intraperitoneal |
400mg/kg (400mg/kg) |
? |
Toksikologicheskii Vestnik. Vol. (2), Pg. 34, 1998. |
| mouse |
LD50 |
intravenous |
132mg/kg (132mg/kg) |
? |
Journal of Chemotherapy. Vol. 5, Pg. 400, 1993.
? |
| mouse |
LD50 |
oral |
2764mg/kg (2764mg/kg) |
? |
United States Patent Document. Vol. #4180578, |
| mouse |
LD50 |
subcutaneous |
> 5gm/kg (5000mg/kg) |
? |
Chemotherapy Vol. 21, Pg. 175, 1973. |
| rat |
LD50 |
intraperitoneal |
500mg/kg (500mg/kg) |
? |
Toksikologicheskii Vestnik. Vol. (2), Pg. 34, 1998. |
| rat |
LD50 |
oral |
> 5300mg/kg (5300mg/kg) |
? |
Toksikologicheskii Vestnik. Vol. (2), Pg. 34, 1998. |
| rat |
LD50 |
subcutaneous |
> 5gm/kg (5000mg/kg) |
? |
Chemotherapy Vol. 21, Pg. 175, 1973. |
| women |
TDLo |
oral |
56mg/kg/7D-I (56mg/kg) |
KIDNEY, URETER, AND BLADDER: HEMATURIA
BLOOD: OTHER CHANGES
MUSCULOSKELETAL: JOINTS |
Postgraduate Medical Journal. Vol. 68, Pg. 391, 1992. |
| women |
TDLo |
oral |
60mg/kg/10D-I (60mg/kg) |
BLOOD: THROMBOCYTOPENIA |
New Zealand Medical Journal. Vol. 106, Pg. 251, 1993.
? |
