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1-Butanol,2,2'-(1,2-ethanediyldiimino)bis-, (2S,2'S)- cas no:74-55-5

Synonyms: 1-Butanol,2,2'-(1,2-ethanediyldiimino)bis-, [S-(R*,R*)]-;1-Butanol,2,2'-(ethylenediimino)di-, (+)- (8CI);(+)-Ethambutol;(+)-N,N'-Bis[1-(hydroxymethyl)propyl]ethylenediamine;(+)-S,S-Ethambutol;(2S,7S)-2,7-Diethyl-3,6-diazaoctane-1,8-diol;(S,S)-Ethambutol;Diambutol;EMB;Purderal;d-2,2'-(Ethylenediimino)bis(1-butanol);d-2,2'-(Ethylenediimino)di-1-butanol;d-Ethambutol;d-N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine;

Identification
Name1-Butanol,2,2'-(1,2-ethanediyldiimino)bis-, (2S,2'S)-
CAS74-55-5
Synonyms1-Butanol,2,2'-(1,2-ethanediyldiimino)bis-, [S-(R*,R*)]-;1-Butanol,2,2'-(ethylenediimino)di-, (+)- (8CI);(+)-Ethambutol;(+)-N,N'-Bis[1-(hydroxymethyl)propyl]ethylenediamine;(+)-S,S-Ethambutol;(2S,7S)-2,7-Diethyl-3,6-diazaoctane-1,8-diol;(S,S)-Ethambutol;Diambutol;EMB;Purderal;d-2,2'-(Ethylenediimino)bis(1-butanol);d-2,2'-(Ethylenediimino)di-1-butanol;d-Ethambutol;d-N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine;
EINECS(EC#)200-810-6
Molecular FormulaC10H24N2O2
Molecular Weight204.31
Chemical Properties
Appearancewhite crystalline hygroscopic powder
refractive index1.5738 (20 C)
storage tempKeep tightly closed. Store at 2-8 C
Safety Data

Hazard UN NO.
Safety Hazardous Substances Data:74-55-5(Hazardous Substances Data)

Toxicity

Organism

Test Type

Route

Reported Dose (Normalized Dose)

Effect

Source

human

TDLo

oral

1410mg/kg/11W (1410mg/kg)

sense organs and special senses: visual field changes: eye

New Zealand Medical Journal. Vol. 111, Pg. 428, 1998.

mammal (species unspecified)

LD50

intravenous

350mg/kg (350mg/kg)

lungs, thorax, or respiration: other changes

Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63(3), Pg. 114S, 1967.

mammal (species unspecified)

LD50

subcutaneous

890mg/kg (890mg/kg)

lungs, thorax, or respiration: other changes

Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63(3), Pg. 114S, 1967.

man

TDLo

oral

332mg/kg/31D- (332mg/kg)

lungs, thorax, or respiration: "fibrosis, focal (pneumoconiosis)"
blood: eosinophilia

Journal of Allergy and Clinical Immunology. Vol. 100, Pg. 712, 1997.

man

TDLo

oral

600mg/kg (600mg/kg)

peripheral nerve and sensation: structural change in nerve or sheath
behavioral: changes in motor activity (specific assay)
kidney, ureter, and bladder: other changes in urine composition

British Medical Journal. Vol. 2, Pg. 1105, 1976.

man

TDLo

oral

1200mg/kg (1200mg/kg)

skin and appendages (skin): "dermatitis, other: after systemic exposure"

British Medical Journal. Vol. 2, Pg. 1105, 1976.

mouse

LD50

intraperitoneal

1075mg/kg (1075mg/kg)

behavioral: convulsions or effect on seizure threshold

Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 23, Pg. 463, 1971.

mouse

LD50

intravenous

240mg/kg (240mg/kg)

behavioral: convulsions or effect on seizure threshold

Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 23, Pg. 463, 1971.

mouse

LD50

oral

8700mg/kg (8700mg/kg)

behavioral: convulsions or effect on seizure threshold

Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 23, Pg. 463, 1971.

rat

LD50

oral

998mg/kg (998mg/kg)

 

Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.

women

TDLo

oral

900mg/kg/60D- (900mg/kg)

liver: "jaundice, cholestatic"

British Medical Journal. Vol. 292, Pg. 866, 1986.

supplier list

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R. P. Traders
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