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Prostaglandin E1 cas no:745-65-3

Synonyms: ALPROSTADIL; Prostaglandin E1 or AIPROSTADIL; Alprostadil (prostandin E1)

Identification
NameProstaglandin E1
CAS745-65-3
SynonymsALPROSTADIL; Prostaglandin E1 or AIPROSTADIL; Alprostadil (prostandin E1)
EINECS(EC#)212-017-2
Molecular FormulaC20H34O5
Molecular Weight354.48
Chemical Properties
Appearancewhite to off-white crystalline powder
alpha-64 o (C=1.0, C2H5OH)
storage temp?20°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xn:Harmful
Risk R22
Safety

Safety Information of Alprostadil (CAS NO.745-65-3):
Hazard Codes: XnHarmful,XiIrritant
Risk Statements: 22-36/37/38
22:? Harmful if swallowed?
36:? Irritating to the eyes?
37:? Irritating to the respiratory system?
38:? Irritating to the skin?
Safety Statements: 36-26
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
36:? Wear suitable protective clothing


HS Code 29375000

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 19800ug/kg (19.8mg/kg) ? Drugs in Japan Vol. 6, Pg. 47, 1982.
mouse LD50 intravenous 21mg/kg (21mg/kg) ? Drugs in Japan Vol. 6, Pg. 47, 1982.
mouse LD50 oral 186mg/kg (186mg/kg) ? Drugs in Japan Vol. 6, Pg. 47, 1982.
mouse LD50 subcutaneous 26400ug/kg (26.4mg/kg) ? Drugs in Japan Vol. 6, Pg. 47, 1982.
rat LD50 intraarterial 21mg/kg (21mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 499, 1983.
rat LD50 intraperitoneal 24900ug/kg (24.9mg/kg) ? Drugs in Japan Vol. 6, Pg. 47, 1982.
rat LD50 intravenous 19200ug/kg (19.2mg/kg) ? Drugs in Japan Vol. 6, Pg. 47, 1982.
rat LD50 oral 228mg/kg (228mg/kg) ? Drugs in Japan Vol. 6, Pg. 47, 1982.
rat LD50 subcutaneous 18600ug/kg (18.6mg/kg) ? Drugs in Japan Vol. 6, Pg. 47, 1982.

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