1-Butanone,1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]- cas no:749-13-3

Name1-Butanone,1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-
CAS749-13-3
SynonymsButyrophenone,4'-fluoro-4-[4-hydroxy-4-(a,a,a-trifluoro-m-tolyl)piperidino]- (6CI,7CI,8CI);4'-Fluoro-4-[4-hydroxy-4-(a,a,a-trifluoro-m-tolyl)piperidino]butyrophenone;Flumoperone; McN-JR 2498; NSC 170978; P 459; Psicoperidol; R 2498;Trifluoperidol; Trifluperidol; Trifluperol; Triperidol; Trisedil; p-Fluoro-g-[4-hydroxy-4-(3-trifluoromethylphenyl)piperidino]butyrophenone
Molecular FormulaC22H23 F4 N O2
Molecular Weight409.46

refractive index1.534

Safety

Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F⁻ and NO_x. See also FLUORIDES and TRIFLUPERIDOL HYDROCHLORIDE.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	subcutaneous	> 2500ug/kg (2.5mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
dog	LD50	subcutaneous	> 80mg/kg (80mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
monkey	LD50	subcutaneous	> 1250ug/kg (1.25mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LD50	intravenous	26mg/kg (26mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LD50	oral	110mg/kg (110mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1248, 1974.
mouse	LD50	subcutaneous	50mg/kg (50mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1248, 1974.
mouse	LDLo	intraperitoneal	150mg/kg (150mg/kg)		National Technical Information Service. Vol. AD691-490,
rat	LD50	intravenous	14mg/kg (14mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
rat	LD50	oral	140mg/kg (140mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat	LD50	subcutaneous	70mg/kg (70mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE AUTONOMIC NERVOUS SYSTEM: CENTRAL SYMPATHOLYTIC BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING	Medicinal Chemistry: A Series of Monographs. Vol. 4(2), Pg. 199, 1967.