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Acetonitrile cas no:75-05-8

Synonyms: AN; Methyl cyanide; acetonitrile for uv-spectroscopy; acetonitrile B&J brand 4 L; acetonitrile absolute over molecular sieve (H2O <0.001%); Acetonitrile solution; ACETONITRILE GRADIENT; phosphoramidite diluent for pharmacia; cyanomethane

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Identification
NameAcetonitrile
CAS75-05-8
SynonymsAN; Methyl cyanide; acetonitrile for uv-spectroscopy; acetonitrile B&J brand 4 L; acetonitrile absolute over molecular sieve (H2O <0.001%); Acetonitrile solution; ACETONITRILE GRADIENT; phosphoramidite diluent for pharmacia; cyanomethane
EINECS(EC#)200-835-2
Molecular FormulaC2H3N
Molecular Weight41.05
Chemical Properties
AppearanceClear liquid
refractive index1.343-1.345
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass3
Safety Data

Hazard F:Flammable
Risk R11;R20/21/22;R36
Safety

Hazard Codes:?F,Xi,Xn,T
Risk Statements: 11-20/21/22-10-36/37/38-23/24/25-41?
R10: Flammable.
R11: Highly flammable.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.?
R41: Risk of serious damage to the eyes.
Safety Statements: 16-45-36/37/39-27-26?
S16: Keep away from sources of ignition.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S27: Take off immediately all contaminated clothing.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)


HS Code 29269095

Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LC50 inhalation 18gm/m3 (18000mg/m3) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 16, 1982.
cat LD50 oral 200mg/kg (200mg/kg) ? Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. Vol. 19, Pg. 225, 1969.
child TDLo oral 800mg/kg (800mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
GASTROINTESTINAL: NAUSEA OR VOMITING		 American Journal of Emergency Medicine. Vol. 9, Pg. 268, 1991.
dog LCLo inhalation 16000ppm/4H (16000ppm) ? Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
frog LDLo subcutaneous 9100mg/kg (9100mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 5, Pg. 161, 1899.
guinea pig LC50 inhalation 5655ppm/4H (5655ppm) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BLOOD: HEMORRHAGE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
guinea pig LD50 oral 177mg/kg (177mg/kg) ? Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
human TCLo inhalation 160ppm/4H (160ppm) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 65, 1969.
mammal (species unspecified) LD50 oral 1670mg/kg (1670mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
man TDLo oral 64mg/kg (64mg/kg) BEHAVIORAL: EXCITEMENT Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 447, 1991.
man TDLo oral 571mg/kg (571mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
GASTROINTESTINAL: NAUSEA OR VOMITING		 Acta Pharmacologica et Toxicologica, Supplementun. Vol. 41, Pg. 340, 1977.
mouse LC50 inhalation 2693ppm/1H (2693ppm) LIVER: OTHER CHANGES Clinical Toxicology. Vol. 18, Pg. 991, 1981.
mouse LD50 intraperitoneal 175mg/kg (175mg/kg) SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 59, Pg. 589, 1981.
mouse LD50 intravenous 612mg/kg (612mg/kg) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 16, 1982.
mouse LD50 oral 269mg/kg (269mg/kg) ? Archives of Toxicology. Vol. 55, Pg. 47, 1984.
mouse LD50 subcutaneous 4480mg/kg (4480mg/kg) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 16, 1982.
rabbit LC50 inhalation 2828ppm/4H (2828ppm) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BLOOD: HEMORRHAGE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
rabbit LD50 oral 50mg/kg (50mg/kg) ? Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. Vol. 19, Pg. 225, 1969.
rabbit LD50 skin > 2gm/kg (2000mg/kg) ? International Journal of Toxicology. Vol. 19, Pg. 363, 2000.
rabbit LDLo subcutaneous 105mg/kg (105mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 455, 1929.
rat LC50 inhalation 7551ppm/8H (7551ppm) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BLOOD: HEMORRHAGE		 Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
rat LD50 intraperitoneal 850mg/kg (850mg/kg) ? Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
rat LD50 intravenous 1680mg/kg (1680mg/kg) ? Journal of Occupational Medicine. Vol. 1, Pg. 634, 1959.
rat LD50 oral 2460mg/kg (2460mg/kg) ? Union Carbide Data Sheet. Vol. 3/18/1965,
rat LD50 parenteral 1100mg/kg (1100mg/kg) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 16, 1982.
rat LD50 subcutaneous 3500mg/kg (3500mg/kg) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 16, 1982.
women TDLo oral 500mg/kg (500mg/kg) BEHAVIORAL: COMA
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Postgraduate Medical Journal. Vol. 73, Pg. 299, 1997.
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