Lovastatin cas no:75330-75-5
Synonyms: MK-803;Belvas;(1S-(1alpha(R),3alpha,7beta,8beta(2S,4S),8abeta))-(1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthyl) 2-methylbutanoate;Rodatin;Paschol;Artein;Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-- oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-;Sivlor;MK 803;Mevinolin;Prestwick_819;Antibiotic MB 530B;Lestatin;Colevix;Lovastation;Mevinacor;Lovasterol;[(1S,3R,7R,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate;2-Methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid;Hipolip;Tecnolip;Lovastatine [French];6-alpha-Methylcompactin;MSD 803;Cholestra;Lovastatin (USP);ML-530B;Monacolin K;Hipovastin;Taucor;Mevacor (TN);[(1S,3R,7R,8S,8aR)-8-[2-[(4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate;Teroltrat;Lozutin;Lipofren;Lipdip;
NameLovastatin
CAS75330-75-5
SynonymsMK-803;Belvas;(1S-(1alpha(R),3alpha,7beta,8beta(2S,4S),8abeta))-(1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthyl) 2-methylbutanoate;Rodatin;Paschol;Artein;Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-- oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-;Sivlor;MK 803;Mevinolin;Prestwick_819;Antibiotic MB 530B;Lestatin;Colevix;Lovastation;Mevinacor;Lovasterol;[(1S,3R,7R,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate;2-Methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid;Hipolip;Tecnolip;Lovastatine [French];6-alpha-Methylcompactin;MSD 803;Cholestra;Lovastatin (USP);ML-530B;Monacolin K;Hipovastin;Taucor;Mevacor (TN);[(1S,3R,7R,8S,8aR)-8-[2-[(4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate;Teroltrat;Lozutin;Lipofren;Lipdip;
Molecular FormulaC24H36O5
Molecular Weight404.54
AppearanceWhite solid
refractive index320 ° (C=0.5, CH3CN)
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass9
Hazard Xi: Irritant;
Risk R36/37/38
Safety
Hazard Codes of Lovastatin (CAS NO.75330-75-5):?
Xi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36/37/39-26?
S22:Do not breathe dust.?
S24/25:Avoid contact with skin and eyes.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 3077
WGK Germany: 3
RTECS: EK7907000
HazardClass: 9
PackingGroup: III
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| child |
TDLo |
oral |
17mg/kg/3W-I (17mg/kg) |
BEHAVIORAL: WAKEFULNESS |
Lancet. Vol. 343, Pg. 973, 1994. |
| human |
TDLo |
oral |
8750ug/kg/14D (8.75mg/kg) |
BEHAVIORAL: WAKEFULNESS
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) |
Clinical Pharmacology and Therapeutics Vol. 50, Pg. 730, 1991. |
| man |
TDLo |
oral |
240mg/kg/60W- (240mg/kg) |
BEHAVIORAL: MUSCLE WEAKNESS |
Annals of Pharmacotherpy. Vol. 26, Pg. 190, 1992. |
| mouse |
LD50 |
oral |
> 1gm/kg (1000mg/kg) |
? |
Journal of Antibiotics. Vol. 32, Pg. 852, 1979. |
| women |
TDLo |
oral |
285mg/kg/30W- (285mg/kg) |
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
LIVER: LIVER FUNCTION TESTS IMPAIRED
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Israel Journal of Medical Sciences. Vol. 28, Pg. 101, 1992. |
