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Urea,N-ethyl-N-nitroso- cas no:759-73-9

Synonyms: Urea,1-ethyl-1-nitroso- (7CI,8CI); 1-Ethyl-1-nitrosourea; ENU;N-Ethyl-N-nitrosourea; N-Nitroso-N-ethylurea; NSC 45403

Identification
NameUrea,N-ethyl-N-nitroso-
CAS759-73-9
SynonymsUrea,1-ethyl-1-nitroso- (7CI,8CI); 1-Ethyl-1-nitrosourea; ENU;N-Ethyl-N-nitrosourea; N-Nitroso-N-ethylurea; NSC 45403
EINECS(EC#)212-072-2
Molecular FormulaC3H7 N3 O2
Molecular Weight117.13
Chemical Properties
refractive index1.532
storage temp−20°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard T
Risk 45-46-61-20/21/22
Safety

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.Safety information of 1-Ethyl-1-nitrosourea (CAS NO.759-73-9):
Hazard Codes  ToxicT
Risk Statements 
45 May cause cancer
46 May cause heritable genetic damage
61 May cause harm to the unborn child
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
Safety Statements 
53 Avoid exposure - obtain special instruction before use
22 Do not breathe dust
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  YT3150000
HazardClass  6.1(b)
PackingGroup  III


Toxicity
1.    

dni-hmn:hla 100 µmol/L

    MUREAV    Mutation Research. 92 (1982),427.
2.    

cyt-ham-orl 100 mg/kg

    TRENAF    Kenkyu Nenpo-Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. 36 (1985),396.
3.    

orl-rat TDLo:10 mg/kg (female 19D post):NEO,TER

    CALEDQ    Cancer Letters (Shannon, Ireland). 2 (1976),93.
4.    

skn-rat TDLo:350 mg/kg (female 16-22D post):NEO,TER

    ZEKBAI    Zeitschrift fuer Krebsforschung. 81 (1974),169.
5.    

ipr-rat TDLo:10 mg/kg (female 15D post):NEO,TER

    SCIEAS    Science. 218 (1982),682.
6.    

ivn-rat TDLo:50 mg/kg (15D preg):CAR,TER

    ZEKBAI    Zeitschrift fuer Krebsforschung. 73 (1970),371.
7.    

unr-rat TDLo:5 mg/kg (13D preg):ETA,TER

    XENOBH    Xenobiotica. 3 (1973),271.
8.    

ipr-mus TDLo:20 mg/kg (19D preg):CAR,TER

    VOONAW    Voprosy Onkologii. Problems of Onkology. 23 (3)(1977),41.
9.    

par-mus TDLo:100 mg/kg/(18D preg):ETA,TER

    PAACA3    Proceedings of the American Association for Cancer Research. 17 (1976),122.
10.    

par-mus TDLo:58,565 µg/kg (18D preg):CAR,TER

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