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bornan-2-one cas no:76-22-2

Synonyms: Camphor synthetic; plus-minus-camphor; Camphor Natural,Tablet; Synthetic Camphor; 1,7,7-Trimethyl-bicyclo[2.2.1]heptan-2-on; 3-Chloro-4-methylphenyl isocyanate

Identification
Namebornan-2-one
CAS76-22-2
SynonymsCamphor synthetic; plus-minus-camphor; Camphor Natural,Tablet; Synthetic Camphor; 1,7,7-Trimethyl-bicyclo[2.2.1]heptan-2-on; 3-Chloro-4-methylphenyl isocyanate
EINECS(EC#)200-945-0
Molecular FormulaC10H16O
Molecular Weight152.23
Chemical Properties
Appearancecolorless or white colored crystalline powder with a strong mothball-like odor
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass4.1
Safety Data

Hazard F:Flammable
Risk R11;R36/37/38
Safety

A human poison by ingestion and possibly other routes. An experimental poison by inhalation, subcutaneous, and intraperitoneal routes. A local irritant. Ingestion causes nausea, vomiting, dizziness, excitation, and convulsions. Mutation data reported. Used as a topical anti-infective and anti-itching agent. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. Vapor is explosive when exposed to heat or flame or CrO3. To fight fire, use foam, carbon dioxide, dry chemical.
Hazard Codes:?F,Xn,Xi
Risk Statements: 11-22-36/37/38-20/21/22?
R11:Highly flammable.?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 16-26-37/39?
S16:Keep away from sources of ignition.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S37/39:Wear suitable gloves and eye/face protection.
RIDADR: UN 2717 4.1/PG 3
WGK Germany: 1
RTECS: EX1225000
HazardClass: 4.1
PackingGroup: III


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intraperitoneal 400mg/kg (400mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
child LDLo unreported 100mg/kg (100mg/kg) ? Yakkyoku. Pharmacy. Vol. 31, Pg. 1499, 1980.
child TDLo oral 51mg/kg (51mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
American Journal of Emergency Medicine. Vol. 7, Pg. 41, 1989.
dog LDLo oral 800mg/kg (800mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog LDLo subcutaneous 240mg/kg (240mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.
infant LDLo oral 70mg/kg (70mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
American Journal of Pathology. Vol. 30, Pg. 857, 1954.
man LDLo unreported 29mg/kg (29mg/kg) ? "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LCLo inhalation 400mg/m3/3H (400mg/m3) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 22(11), Pg. 83, 1957.
mouse LD50 intraperitoneal 3gm/kg (3000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
American Journal of Pathology. Vol. 30, Pg. 857, 1954.
mouse LD50 oral 1310mg/kg (1310mg/kg) ? Shika Gakuho. Journal of Dentistry. Vol. 75, Pg. 934, 1975.
mouse LDLo subcutaneous 200mg/kg (200mg/kg) BEHAVIORAL: EXCITEMENT "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933Vol. -, Pg. -, 1933.
rabbit LDLo oral 2gm/kg (2000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: REGIDITY
American Journal of Pathology. Vol. 30, Pg. 857, 1954.
rat LD50 subcutaneous 70mg/kg (70mg/kg) ? "Ueber die Pharmakologische Wirkung eines dem Pentamethylentetrazol Vol. -, Pg. -, 1934.
rat LDLo intraperitoneal 900mg/kg (900mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 275, 1939.

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