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Methoxyflurane cas no:76-38-0

Synonyms: 1,1-difluoro-2,2-dichloroethyl methyl ether; 2,2-dichloro-1,1-difluoro-1-methoxyethane; 2,2-Dichloro-1,1-difluoroethyl methyl ether; analgizer; anecotan; DA759; ingalan; inhalan; Methflurane; methoflurane; methoxane; Methoxflurane; METHOXYFLURANE (METOFANE); metofane; metoxfluran; metoxifluran; MOF; penthrane; Pentrane

Identification
NameMethoxyflurane
CAS76-38-0
Synonyms1,1-difluoro-2,2-dichloroethyl methyl ether; 2,2-dichloro-1,1-difluoro-1-methoxyethane; 2,2-Dichloro-1,1-difluoroethyl methyl ether; analgizer; anecotan; DA759; ingalan; inhalan; Methflurane; methoflurane; methoxane; Methoxflurane; METHOXYFLURANE (METOFANE); metofane; metoxfluran; metoxifluran; MOF; penthrane; Pentrane
EINECS(EC#)200-956-0
Molecular FormulaC3H4Cl2F2O
Molecular Weight164.96
Chemical Properties
Appearancecolourless liquid
refractive index1.386
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass3
Safety Data

Hazard Xi
Risk R10
Safety

Moderately toxic by ingestion. Mildly toxic by inhalation. Human systemic effects by inhalation: depressed renal function. An experimental teratogen. Human mutation data reported. An eye irritant. See also ETHERS. When heated to decomposition it emits very toxic fumes of Cl and F.
Hazard Codes: Xi
Risk Statements: 10
R10:Flammable.
Safety Statements: 23-24/25 
S23:Do not breathe vapour. 
S24/25:Avoid contact with skin and eyes.


Toxicity
1.    

eye-rbt 100 mg MOD

    FEPRA7    Federation Proceedings, Federation of American Societies for Experimental Biology. 35 (1976),729.
2.    

cyt-hmn:lym 200 ppm/24H

    ENVRAL    Environmental Research. 12 (1976),366.
3.    

oms-ham:fbr 1 pph

    ANESAV    Anesthesiology. 43 (1975),21.
4.    

ihl-rat TCLo:100 ppm/8H (1-21D preg):TER

    ANESAV    Anesthesiology. 48 (1978),11.
5.    

ihl-hmn TCLo:3500 ppm/1H:KID

    CANJAE    Canadian Anaesthetists Society Journal. 21 (1974),294.
6.    

orl-rat LD50:3600 mg/kg

    85GMAT    Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,53.
7.    

ihl-rat LC50:33,500 mg/m3/4H

    85GMAT    Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,53.
8.    

ihl-mus LC50:21,500 mg/m3

    GTPZAB    Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 22 (7)(1978),55.

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