Sodium nitrite cas no:7632-00-0

NameSodium nitrite
CAS7632-00-0
SynonymsSodium nitrite,food grade
EINECS(EC#)231-555-9
Molecular FormulaNaNO2
Molecular Weight68.99

Appearancewhite to off-white powder
storage temp2-8°C
Sensitive Hygroscopic

Hazardclass5.1

Hazard T:Toxic
Risk R25;R50;R8
Safety

Hazard Codes:?O,T,N,Xn
Risk Statements: 8-25-50-22-36/38?
R8 :Contact with combustible material may cause fire.?
R25 :Toxic if swallowed.?
R50:Very toxic to aquatic organisms.?
R22:Harmful if swallowed.?
R36/38:Irritating to eyes and skin.
Safety Statements: 45-61-36-26?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.?
S36:Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 3219 5.1/PG 3
WGK Germany: 3
RTECS: RA1225000
F: 10
HazardClass: 5.1
PackingGroup: III
HS Code: 28341000
Human poison by ingestion. Experimental poison by ingestion, inhalation, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: motor activity changes, coma, decreased blood pressure with possible pulse rate increase without fall in blood pressure, arteriolar or venous dilation, nausea or vomiting, and blood methemoglobinemia-carboxyhemoglobinemia. Experimental teratogenic and reproductive effects. An eye irritant. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Human mutation data reported. It may react with organic amines in the body to form carcinogenic nitrosamines.
Flammable; a strong oxidizing agent. In contact with organic matter, will ignite by friction. May explode when heated to over 1000°F or on contact with cyanides, NH₄⁺ salts, cellulose, Li, (K + NH₃), Na₂S₂O₃. Incompatible with aminoguanidine salts, butadiene, phthalic acid, phthalic anhydride, reductants, sodium amide, sodium disulfite, sodium thiocyanate, urea wood. When heated to decomposition it emits toxic fumes of NO_x and Na₂O. See also NITRITES.

HS Code 28341000

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	1500mg/kg (1500mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935.
cat	LDLo	subcutaneous	35mg/kg (35mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 126, Pg. 209, 1927.
chicken	LD50	oral	28944ug/kg (28.944mg/kg)	?	American Journal of Veterinary Research. Vol. 30, Pg. 2185, 1969.
child	LDLo	oral	22mg/kg (22mg/kg)	VASCULAR: OTHER CHANGES	Lancet. Vol. 2, Pg. 162, 1917.
dog	LDLo	intravenous	15mg/kg (15mg/kg)	?	"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 245, 1973.
dog	LDLo	oral	330mg/kg (330mg/kg)	?	"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 245, 1973.
dog	LDLo	subcutaneous	60mg/kg (60mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 21, Pg. 425, 1911.
frog	LDLo	subcutaneous	1gm/kg (1000mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935.
human	LDLo	oral	71mg/kg (71mg/kg)	BEHAVIORAL: COMA GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 543, 1969.
human	TDLo	oral	14mg/kg (14mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION GASTROINTESTINAL: NAUSEA OR VOMITING	Deutsche Medizinische Wochenschrift. Vol. 74, Pg. 961, 1949.
man	LDLo	oral	321mg/kg (321mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Israel Journal of Medical Sciences. Vol. 28, Pg. 289, 1992.
man	TDLo	oral	1714ug/kg/70M (1.714mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Clinical Investigation. Vol. 16, Pg. 73, 1937.
mouse	LD50	intraperitoneal	158mg/kg (158mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 165, Pg. 30, 1969.
mouse	LD50	oral	175mg/kg (175mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION	FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 97, 1974.
mouse	LDLo	subcutaneous	150mg/kg (150mg/kg)	BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
rabbit	LD50	oral	186mg/kg (186mg/kg)	?	Southwestern Veterinarian. Vol. 27, Pg. 246, 1974.
rabbit	LDLo	intravenous	80mg/kg (80mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: COMA KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 121, 1931.
rabbit	LDLo	subcutaneous	60mg/kg (60mg/kg)	?	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935.
rat	LC50	inhalation	5500ug/m3/4H (5.5mg/m3)	?	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(10), Pg. 36, 1972.
rat	LD50	intravenous	65mg/kg (65mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 320, 1963.
rat	LD50	oral	180mg/kg (180mg/kg)	?	American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat	LD50	subcutaneous	96600ug/kg (96.6mg/kg)	?	Archives of Toxicology, Supplement. Vol. 14, Pg. 231, 1991.