1-9-Luteinizinghormone-releasing factor (swine),6-[1-(phenylmethyl)-D-histidine]-9-(N-ethyl-L-prolinamide)- cas no:76712-82-8

Name1-9-Luteinizinghormone-releasing factor (swine),6-[1-(phenylmethyl)-D-histidine]-9-(N-ethyl-L-prolinamide)-
CAS76712-82-8
SynonymsLuteinizinghormone-releasing factor (pig),6-[1-(phenylmethyl)-D-histidine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-;Histrelin; ORF 17070; RWJ 17070; Vantas
Molecular FormulaC66H86 N18 O12
Molecular Weight1323.50244

AppearanceWhite or almost white lyophilized powder
storage temp−20°C

Hazard T: Toxic;
Risk R60
Safety

Hazard Codes: T
Risk Statements: 60
R60:May impair fertility.
Safety Statements: 53-22-36/37/39-45
S53:Avoid exposure - obtain special instructions before use. 
S22:Do not breathe dust. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: OK6370800

CHEMICAL IDENTIFICATION

RTECS NUMBER :

OK6370800

CHEMICAL NAME :

Luteinizing hormone releasing factor (pig), 6-(1-(phenylmethyl)-D-histidine)-9-(N-ethyl-L- prolinamide)-10-deglycinamide-

CAS REGISTRY NUMBER :

76712-82-8

LAST UPDATED :

199612

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C66-H86-N18-O12

MOLECULAR WEIGHT :

1323.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

46 ug/kg

SEX/DURATION :

male 2 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male

REFERENCE :

JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 7,140,1986

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

4667 ug/kg

SEX/DURATION :

male 8 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :

JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 7,140,1986

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

2333 ug/kg

SEX/DURATION :

male 4 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :

JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 7,140,1986