Phenolphthalein cas no:77-09-8

NamePhenolphthalein
CAS77-09-8
SynonymsPhenolphthalein solution; 3,3-bis(p-hydroxyphenyl)phthalide; ,3-bis(4-hydroxyphenyl)-1(3H)-isobenzofuranore
EINECS(EC#)201-004-7
Molecular FormulaC20H14O4
Molecular Weight318.33

Appearanceodourless white to cream powder
refractive index1.57 (7.9 C)
storage tempKeep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

Hazard Xn:Harmful
Risk R22;R40
Safety Hazard Codes:Xn,T,F,Xi
Risk Statements:40-22-10-36/38-23/25-11-36/37/38
40:Limited evidence of a carcinogenic effect
22:Harmful if swallowed
10:Flammable
36/38:Irritating to eyes and skin
23/25:Toxic by inhalation and if swallowed
11:Highly Flammable
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:45-36/37-33-24-16-7-36-26
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37:Wear suitable protective clothing and gloves
33:Take precautionary measures against static discharges
24:Avoid contact with skin
16:Keep away from sources of ignition - No smoking
7:Keep container tightly closed
36:Wear suitable protective clothing
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR:UN 1993
HS Code:29322910
Hazardous Substances Data:77-09-8(Hazardous Substances Data)

HS Code 29322910

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SM8380000

CHEMICAL NAME :

Phenolphthalein

CAS REGISTRY NUMBER :

77-09-8

BEILSTEIN REFERENCE NO. :

0284423

LAST UPDATED :

199803

DATA ITEMS CITED :

20

MOLECULAR FORMULA :

C20-H14-O4

MOLECULAR WEIGHT :

318.34

WISWESSER LINE NOTATION :

T56 BVO DHJ D- D-/R DQ 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

29 mg/kg

TOXIC EFFECTS :

Gastrointestinal - gastritis Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

324 gm/kg/13W-C

TOXIC EFFECTS :

Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

106 gm/kg/13W-C

TOXIC EFFECTS :

Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

364 gm/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

281 gm/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Skin and Appendages - tumors

TYPE OF TEST :

Micronucleus test

MUTATION DATA

TYPE OF TEST :

Cytogenetic analysis

TEST SYSTEM :

Rodent - hamster Ovary

DOSE/DURATION :

50 mg/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 341,151,1995 *** REVIEWS *** TOXICOLOGY REVIEW DAPOAG Deutsche Apotheker. (Postfach 1650, 6370 Oberusel/Taunas, Fed. Rep. Ger.) V.1- 1949- Volume(issue)/page/year: 27,151,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0011 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 31 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 56240 No. of Facilities: 6160 (estimated) No. of Industries: 102 No. of Occupations: 43 No. of Employees: 43092 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9187 No. of Facilities: 117 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1946 (estimated) No. of Female Employees: 1408 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 56240 No. of Facilities: 6900 (estimated) No. of Industries: 89 No. of Occupations: 57 No. of Employees: 73297 (estimated) No. of Female Employees: 18309 (estimated)