Milbemycin B,5-O-demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)-, (6R,25R)- cas no:77855-81-3

NameMilbemycin B,5-O-demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)-, (6R,25R)-
CAS77855-81-3
SynonymsSpiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2'-[2H]pyran],milbemycin B deriv.; Antibiotic B 41D; Milbemycin D
Molecular FormulaC33H48 O7
Molecular Weight424.06

refractive index1.57

Safety

Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits acrid smoke and irritating fumes.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	668mg/kg (668mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.
mouse	LD50	oral	1610mg/kg (1610mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	BLOOD: HEMORRHAGE BLOOD: CHANGES IN SPLEEN	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.
rat	LD50	intraperitoneal	> 2gm/kg (2000mg/kg)		Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.
rat	LD50	oral	2467mg/kg (2467mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.
rat	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	BLOOD: HEMORRHAGE BLOOD: CHANGES IN SPLEEN	Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.