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Tetraethyl orthosilicate cas no:78-10-4

Synonyms: Ethylsilicate ((EtO)4Si) (6CI);Colcoat 6P;Conservare OH;Dynasil A;ES 100;ES 100(silicate);ES 140;ES 28 (ester);Ethyl Silicate 45;Ethyl silicate 28;Ethyl silicate 28P;KIEM-Silex OH;LS 2340;NSC 4790;PETEOS;PG121;Remmers 300;SI 42;SOTEOS;Silane, tetraethoxy-;Silicon ethoxide;Silicon tetraethoxide;Silicon tetraethoxide(Si(OC2H5)4);T 0100;T 0100(ester);TEOS;TEOS Pure;TES 28;TSL 8124;TSLB 124;Tetraethoxysilane;Tetraethoxysilicon(IV);Tetraethyl silicate;Unisilan 74;WD 932;Ethyl silicate;

Identification
NameTetraethyl orthosilicate
CAS78-10-4
SynonymsEthylsilicate ((EtO)4Si) (6CI);Colcoat 6P;Conservare OH;Dynasil A;ES 100;ES 100(silicate);ES 140;ES 28 (ester);Ethyl Silicate 45;Ethyl silicate 28;Ethyl silicate 28P;KIEM-Silex OH;LS 2340;NSC 4790;PETEOS;PG121;Remmers 300;SI 42;SOTEOS;Silane, tetraethoxy-;Silicon ethoxide;Silicon tetraethoxide;Silicon tetraethoxide(Si(OC2H5)4);T 0100;T 0100(ester);TEOS;TEOS Pure;TES 28;TSL 8124;TSLB 124;Tetraethoxysilane;Tetraethoxysilicon(IV);Tetraethyl silicate;Unisilan 74;WD 932;Ethyl silicate;
EINECS(EC#)201-083-8
Molecular FormulaC8H20O4Si
Molecular Weight208.37
Chemical Properties
Appearancecolourless liquid with an alcohol-like odour
refractive index1.382-1.384
storage tempFlammables area
Sensitive Moisture Sensitive
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass3
Safety Data

Hazard Xn: Harmful;
Risk R10;R20;R36/37
Safety

Poison by intravenous route. Moderately toxic by other routes. A skin, mucous membrane, and severe eye irritant. Narcotic in high concentrations. Flammable liquid when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes?:?HarmfulXn
Risk Statements?: 10-20-36/37?
R10:Flammable.?
R20:Harmful by inhalation.?
R36/37:Irritating to eyes and respiratory system.
Safety Statements?: 16-36/37/39?
S16:Keep away from sources of ignition.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR:? UN 1292 3/PG 3
WGK Germany?: 1
RTECS? :VV9450000


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LCLo inhalation 700ppm/6H (700ppm) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 288, 1940.
mammal (species unspecified) LCLo inhalation 4500mg/m3 (4500mg/m3) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LIVER: FATTY LIVER DEGERATION

BLOOD: OTHER CHANGES
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 3, Pg. 81, 1961.
mouse LCLo inhalation 1gm/m3/2H (1000mg/m3) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 5, Pg. 192, 1963.
mouse LDLo intraperitoneal 830mg/kg (830mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: CHANGES IN SPLEEN
Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 46, Pg. 231, 1991.
rabbit LD50 skin 6300uL/kg (6.3mL/kg) ? Union Carbide Data Sheet. Vol. 7/23/1970,
rabbit LDLo intravenous 400mg/kg (400mg/kg) LUNGS, THORAX, OR RESPIRATION: PLEURAL EFFUSION

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA
Industrial Medicine. Vol. 6, Pg. 660, 1937.
rat LCLo inhalation 1000ppm/4H (1000ppm) ? Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 343, 1949.
rat LD50 oral 6270mg/kg (6270mg/kg) ? Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 60, 1949.

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