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S,S,S-Tributyltrithiophosphate (DEF) cas no:78-48-8

Synonyms: Butylphosphorotrithioate (6CI); B 1,776; Butiphos; Butyl phosphorotrithioate((BuS)3PO); Chemagro B 1776; DEF; DEF 6; DEF Defoliant; De-Green; Fos-Fall A;Fosfall; S,S,S-Tributyl phosphorotrithioate; S,S,S-Tributyl trithiophosphate;TBPT; TBTP; Tribufos

Identification
NameS,S,S-Tributyltrithiophosphate (DEF)
CAS78-48-8
SynonymsButylphosphorotrithioate (6CI); B 1,776; Butiphos; Butyl phosphorotrithioate((BuS)3PO); Chemagro B 1776; DEF; DEF 6; DEF Defoliant; De-Green; Fos-Fall A;Fosfall; S,S,S-Tributyl phosphorotrithioate; S,S,S-Tributyl trithiophosphate;TBPT; TBTP; Tribufos
EINECS(EC#)201-120-8
Molecular FormulaC12H27 O P S3
Molecular Weight314.54
Chemical Properties
refractive index1.516
storage temp0-6°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Hazard T: Toxic;
Risk R24/25
Safety

A poison by ingestion, skin contact, and intraperitoneal routes. Experimental reproductive effects. Animal experiments show an anti-cholinesterase effect. When heated to decomposition it emits toxic fumes of POx and SOx. See also PARATHION, PHOSPHATES, ESTERS, and SULFATES.
 

Hazard Codes: T
Risk Statements:
24:  Toxic in contact with skin
25:  Toxic if swallowed 
Safety Statements:
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo skin 1gm/kg (1000mg/kg) SPINAL CORD: DEMYELINATION
BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 48, Pg. A195, 1979.
guinea pig LD50 intraperitoneal 150mg/kg (150mg/kg) BEHAVIORAL: REGIDITY
BEHAVIORAL: IRRITABILITY
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
AMA Archives of Industrial Health. Vol. 20, Pg. 161, 1959.
guinea pig LD50 oral 140mg/kg (140mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 44, 1982.
mammal (species unspecified) LD50 unreported 170mg/kg (170mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 376, 1971.
mouse LCLo inhalation 3804mg/m3/1H (3804mg/m3)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 199, 1969.
mouse LD50 intraperitoneal 285mg/kg (285mg/kg)   Biochemical Pharmacology. Vol. 12, Pg. 73, 1963.
mouse LD50 oral 77mg/kg (77mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1188, 1986.
rabbit LD50 oral 242mg/kg (242mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
KIDNEY, URETER, AND BLADDER: INCONTINENCE
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 11(4), Pg. 11, 1967.
rabbit LD50 skin 97mg/kg (97mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 44, 1982.
rat LD50 intraperitoneal 210mg/kg (210mg/kg) BEHAVIORAL: REGIDITY
BEHAVIORAL: IRRITABILITY
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
AMA Archives of Industrial Health. Vol. 20, Pg. 161, 1959.
rat LD50 oral 150mg/kg (150mg/kg)   Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969.
rat LD50 skin 168mg/kg (168mg/kg)   World Review of Pest Control. Vol. 9, Pg. 119, 1970.

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