78246-49-8|Paroxetine hydrochlorideProducts Supply

Paroxetine hydrochloride cas no:78246-49-8

Synonyms: Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, hydrochloride,(3S,4R)- (9CI);(-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidinehydrochloride;Aropax 20;BRL 29060 hydrochloride;BRL 29060A;Deroxat;Paroxet;Paxil;Seroxat;Tagonis;Paroxetine Hcl;

Identification

NameParoxetine hydrochloride
CAS78246-49-8
SynonymsPiperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, hydrochloride,(3S,4R)- (9CI);(-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidinehydrochloride;Aropax 20;BRL 29060 hydrochloride;BRL 29060A;Deroxat;Paroxet;Paxil;Seroxat;Tagonis;Paroxetine Hcl;
Molecular FormulaC₁₉H₂₀FNO₃
Molecular Weight365.83

Chemical Properties

Appearancewhite or almost white crystalline powder
storage temp-20°C Freezer

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Safety

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	625ug/kg (0.625mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: HEADACHE GASTROINTESTINAL: NAUSEA OR VOMITING	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 28(Suppl,
man	TDLo	oral	3654ug/kg/14D (3.654mg/kg)	BEHAVIORAL: WAKEFULNESS BEHAVIORAL: SLEEP BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 28(Suppl,
mouse	LD50	intravenous	42mg/kg (42mg/kg)	?	Acta Psychiatrica Scandinavica, Supplementum. Vol. 350, Pg. 31, 1989.
mouse	LD50	oral	378mg/kg (378mg/kg)	?	Acta Psychiatrica Scandinavica, Supplementum. Vol. 350, Pg. 31, 1989.
rat	LD50	intravenous	30mg/kg (30mg/kg)	?	Acta Psychiatrica Scandinavica, Supplementum. Vol. 350, Pg. 31, 1989.
rat	LD50	oral	415mg/kg (415mg/kg)	?	Acta Psychiatrica Scandinavica, Supplementum. Vol. 350, Pg. 31, 1989.
women	TDLo	oral	7400ug/kg/3W- (7.4mg/kg)	BEHAVIORAL: WAKEFULNESS BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: AGGRESSION	Journal of the American Academy of Child and Adolescent Psychiatry. Vol. 36, Pg. 721, 1997.

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Paroxetine hydrochloride cas no:78246-49-8

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