78755-81-4|FlumazenilProducts Supply - Chemical intermediates Network

Flumazenil cas no:78755-81-4

Synonyms: Anexate;Flumazepil;Flumazenil [USAN:BAN:INN];Romazicon;Flumazenilum [Latin];Flumazenil (JAN/USP);Romazicon (TN);4H-Imidazo[1,5-a][1,4]benzodiazepine-3- carboxylic acid,8-fluoro-5,6-dihydro-5- methyl-6-oxo-,ethyl ester;Flumazenilo;Lanexat;Ethyl 8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester;Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;

Identification

NameFlumazenil
CAS78755-81-4
SynonymsAnexate;Flumazepil;Flumazenil [USAN:BAN:INN];Romazicon;Flumazenilum [Latin];Flumazenil (JAN/USP);Romazicon (TN);4H-Imidazo[1,5-a][1,4]benzodiazepine-3- carboxylic acid,8-fluoro-5,6-dihydro-5- methyl-6-oxo-,ethyl ester;Flumazenilo;Lanexat;Ethyl 8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester;Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;
Molecular FormulaC₁₅H₁₄FN₃O₃
Molecular Weight303.29

Chemical Properties

AppearanceColourless crystals
refractive index1.633
storage temp2-8°C

Safety Data

Hazard Xi: Irritant;
Risk R36/37/38
Safety

Hazard Codes? Irritant Xi
Risk Statements 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-27-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S27:Take off immediately all contaminated clothing.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany 2
RTECS NI2922170

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	> 30mg/kg (30mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
dog	LDLo	oral	> 640mg/kg (640mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
man	LDLo	intravenous	5700ng/kg/C (0.0057mg/kg)	CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: CHANGE IN RATE	British Medical Journal. Vol. 304, Pg. 1415, 1992.
mouse	LD50	intraperitoneal	4gm/kg (4000mg/kg)	?	Drugs of the Future. Vol. 7, Pg. 402, 1982.
mouse	LD50	intravenous	143mg/kg (143mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY	Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
mouse	LD50	oral	1300mg/kg (1300mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: REGIDITY	Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
mouse	LDLo	subcutaneous	> 1gm/kg (1000mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rabbit	LD50	oral	2gm/kg (2000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: REGIDITY	Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
rat	LD50	intraperitoneal	1360mg/kg (1360mg/kg)	?	Drugs of the Future. Vol. 7, Pg. 402, 1982.
rat	LD50	intravenous	85mg/kg (85mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY	Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
rat	LD50	oral	4200mg/kg (4200mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: REGIDITY	Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
women	TDLo	intravenous	4ug/kg (0.004mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Pediatric Emergency Care. Vol. 11, Pg. 186, 1995.
women	TDLo	oral	2mg/kg/2D-I (2mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT BEHAVIORAL: AGGRESSION	Lancet. Vol. 339, Pg. 488, 1992.

supplier list

Shanghai pharmaceutical imp&exp co.,ltd: Tel:02162563104; Address: beijing rord 1068,shanghai

ZheJiang Warrant Pharmaceutical Co.,Lcd.: Tel:86-575-85522111; Address: xingbin road,binhai industrial area,shaoxing county,zhejiang,china

Linyi Shengxin Pharmaceutical R&D Co., Ltd: Tel:86-531-58585587; Address: West First of Yufeng Road, Yishui County

Hangzhou Dayangchem Co., Ltd.: Tel:86-571-88938639; Address: 9/F Unit 2 ChangdiTorch Building, 259 #WenSan Road

Nanjing Bangnuo Biotechnology Co., Ltd: Tel:86-1732-7098554; Address: shuanglong road,jiangning, nanjing,jiangsu

Hubei XinRunde Chemical Co., Ltd: Tel:86-27-83214668; Address: East and West Lake District, Wuhan, China

Hubei XinRunde Chemical Co., Ltd: Tel:86-27-83214668; Address: East and West Lake District, Wuhan, China

Nanjing Bangnuo Biotechnology Co., Ltd: Tel:86-1732-7098554; Address: shuanglong road,jiangning, nanjing,jiangsu

Wuhan Dahua Weiye Pharmaceutical Co.,Ltd: Tel:86-27-59335372; Address: daijiashan 45,jiangan economic departmen zone,wuhan,hubei,China

Wuhan Senwayer Century chemical Co.,Ltd: Tel:86-27-59009407; Address: 20#Xudong Street,Wuhan China

Hunan Warrant Pharmaceutical Co., Ltd: Tel:86-731-18390826173; Address: Liuyang Biomedical Park, Changsha City, Hunan Province, China

MOSINTER GROUP LIMITED: Tel:86-574-89212210; Address: Guangbo Center Office 2002, YinXianDaDao 1357

Hangzhou J&H Chemical Co., Ltd: Tel:86-571-87396430; Address: No.200 Zhenhua Rd.Xihu Industrial Park, Hangzhou 310030, China

All Right Chemical Co.,Ltd.: Tel:86-531-55516881; Address: No.22799,Jingshi Road, Jinan,China

All Right Chemical Co.,Ltd.: Tel:86-531-55516881; Address: No.22799,Jingshi Road, Jinan,China

Flumazenil cas no:78755-81-4

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