78755-81-4|FlumazenilProducts Supply - Chemical intermediates Network

Flumazenil cas no:78755-81-4

Synonyms: Anexate;Flumazepil;Flumazenil [USAN:BAN:INN];Romazicon;Flumazenilum [Latin];Flumazenil (JAN/USP);Romazicon (TN);4H-Imidazo[1,5-a][1,4]benzodiazepine-3- carboxylic acid,8-fluoro-5,6-dihydro-5- methyl-6-oxo-,ethyl ester;Flumazenilo;Lanexat;Ethyl 8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester;Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;

Identification

NameFlumazenil
CAS78755-81-4
SynonymsAnexate;Flumazepil;Flumazenil [USAN:BAN:INN];Romazicon;Flumazenilum [Latin];Flumazenil (JAN/USP);Romazicon (TN);4H-Imidazo[1,5-a][1,4]benzodiazepine-3- carboxylic acid,8-fluoro-5,6-dihydro-5- methyl-6-oxo-,ethyl ester;Flumazenilo;Lanexat;Ethyl 8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester;Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;
Molecular FormulaC₁₅H₁₄FN₃O₃
Molecular Weight303.29

Chemical Properties

AppearanceColourless crystals
refractive index1.633
storage temp2-8°C

Safety Data

Hazard Xi: Irritant;
Risk R36/37/38
Safety

Hazard Codes? Irritant Xi
Risk Statements 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-27-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S27:Take off immediately all contaminated clothing.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany 2
RTECS NI2922170

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	> 30mg/kg (30mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
dog	LDLo	oral	> 640mg/kg (640mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
man	LDLo	intravenous	5700ng/kg/C (0.0057mg/kg)	CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: CHANGE IN RATE	British Medical Journal. Vol. 304, Pg. 1415, 1992.
mouse	LD50	intraperitoneal	4gm/kg (4000mg/kg)	?	Drugs of the Future. Vol. 7, Pg. 402, 1982.
mouse	LD50	intravenous	143mg/kg (143mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY	Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
mouse	LD50	oral	1300mg/kg (1300mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: REGIDITY	Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
mouse	LDLo	subcutaneous	> 1gm/kg (1000mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rabbit	LD50	oral	2gm/kg (2000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: REGIDITY	Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
rat	LD50	intraperitoneal	1360mg/kg (1360mg/kg)	?	Drugs of the Future. Vol. 7, Pg. 402, 1982.
rat	LD50	intravenous	85mg/kg (85mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY	Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
rat	LD50	oral	4200mg/kg (4200mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: REGIDITY	Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
women	TDLo	intravenous	4ug/kg (0.004mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Pediatric Emergency Care. Vol. 11, Pg. 186, 1995.
women	TDLo	oral	2mg/kg/2D-I (2mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT BEHAVIORAL: AGGRESSION	Lancet. Vol. 339, Pg. 488, 1992.

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Tianjin Harmony Technology Development Co., Ltd.: Tel:; Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China

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Nectar Industrial Co., Ltd: Tel:+86-755-81009345; Address: shenzhen, Guangdong

Zibo Zhenrong Industrial Trade Co., Ltd.: Tel:+86-533-2869271; Address: No.44 ShiJi Road, Zhangdian District, Zibo City, Shandong Province, China

Taizhou Overseas Int'l Ltd.: Tel:+86-576-8881 2802; Address: 126-8 QINGNIAN ROAD JIAOJIANG TAIZHOU ZHEJIANG CHINA

ABX Advanced Biochemical Compounds GmbH: Tel:+49-(3528)-4041 60; Address: Heinrich-Glaeser-Strasse 10 - 14, Radeberg D-01454,

DSM Pharma Chemicals: Tel:+1-(973)-257-8011; Address: 45 Waterview Blvd, Parsippany, New Jersey 07054-1298,

Santa Cruz Biotechnology, Inc.: Tel:+1-(831)-457-3800; Address: 2145, Delaware Avenue, Santa Cruz, California 95060,

Hubei Biocause Pharmaceutical Co. Ltd: Tel:+86-(27)-65651730; Address: c-7th Floor, Golden trade center, Guantong Garden, 115 Wujia, Jianghan District, Wuhan, Hubei 430023,

Microchem: Tel:+86-(23)-86612540; Address: No.581, Nanping East Road, Nan An, Chong Qing 400060,

Haorui Pharma-Chem Inc.: Tel:+1-(732)-906-7666; Address: 100 Menlo Park Dr, Suite 316, Edison, New Jersey 08837-242,

Feicheng Boyuan Fine Chemicals Co., Ltd.: Tel:; Address:

Wuhan Biocause Pharmaceutlcal Development Co.,Ltd: Tel:+86-27-8422 2527; Address: 4F,2# Building,Hi-Tech Industrial Park,Zhuankou ,Wuhan,430056,Hubei,China

Dalian Huitong International Co., Ltd: Tel:+86-0411-39756198,39792808,84800785; Address: Rm1201,Xinghaiwangzuo Building,no.572 Zhongshan road,Dalian,China

DC Chem Co., Ltd.: Tel:+852-(0)-81324106; Address: Room 1902 (A), 19/F., 38 Plaza, 38 Shan Tung Street, Mongkok, Kowloon,

Flumazenil cas no:78755-81-4

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