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Flumazenil cas no:78755-81-4

Synonyms: Anexate;Flumazepil;Flumazenil [USAN:BAN:INN];Romazicon;Flumazenilum [Latin];Flumazenil (JAN/USP);Romazicon (TN);4H-Imidazo[1,5-a][1,4]benzodiazepine-3- carboxylic acid,8-fluoro-5,6-dihydro-5- methyl-6-oxo-,ethyl ester;Flumazenilo;Lanexat;Ethyl 8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester;Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;

Identification
NameFlumazenil
CAS78755-81-4
SynonymsAnexate;Flumazepil;Flumazenil [USAN:BAN:INN];Romazicon;Flumazenilum [Latin];Flumazenil (JAN/USP);Romazicon (TN);4H-Imidazo[1,5-a][1,4]benzodiazepine-3- carboxylic acid,8-fluoro-5,6-dihydro-5- methyl-6-oxo-,ethyl ester;Flumazenilo;Lanexat;Ethyl 8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester;Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate;
Molecular FormulaC15H14FN3O3
Molecular Weight303.29
Chemical Properties
AppearanceColourless crystals
refractive index1.633
storage temp2-8°C
Safety Data

Hazard Xi: Irritant;
Risk R36/37/38
Safety

Hazard Codes?IrritantXi
Risk Statements 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-27-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S27:Take off immediately all contaminated clothing.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany 2
RTECS NI2922170


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous > 30mg/kg (30mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
dog LDLo oral > 640mg/kg (640mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
man LDLo intravenous 5700ng/kg/C (0.0057mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

CARDIAC: CHANGE IN RATE
British Medical Journal. Vol. 304, Pg. 1415, 1992.
mouse LD50 intraperitoneal 4gm/kg (4000mg/kg) ? Drugs of the Future. Vol. 7, Pg. 402, 1982.
mouse LD50 intravenous 143mg/kg (143mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY
Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
mouse LD50 oral 1300mg/kg (1300mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: REGIDITY
Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
mouse LDLo subcutaneous > 1gm/kg (1000mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rabbit LD50 oral 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: REGIDITY
Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
rat LD50 intraperitoneal 1360mg/kg (1360mg/kg) ? Drugs of the Future. Vol. 7, Pg. 402, 1982.
rat LD50 intravenous 85mg/kg (85mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY
Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
rat LD50 oral 4200mg/kg (4200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: REGIDITY
Journal de Toxicologie Clinique et Experimentale. Vol. 7, Pg. 223, 1987.
women TDLo intravenous 4ug/kg (0.004mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Pediatric Emergency Care. Vol. 11, Pg. 186, 1995.
women TDLo oral 2mg/kg/2D-I (2mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: AGGRESSION
Lancet. Vol. 339, Pg. 488, 1992.

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Address: East and West Lake District, Wuhan, China
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Address: shuanglong road,jiangning, nanjing,jiangsu
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Tel:86-25-52113793
Address: Room 901 Tianqinwan Garden NO.1008 Ssangyong Avenu
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Address: East and West Lake District, Wuhan, China
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