1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)- cas no:79617-96-2
Synonyms: 1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S-cis)-;(+)-Sertraline;(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine;CP 51974;
Name1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-
CAS79617-96-2
Synonyms1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S-cis)-;(+)-Sertraline;(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine;CP 51974;
Molecular FormulaC17H17Cl2N
Molecular Weight306.23
Appearancewhite to off-white powder
Hazard UN NO.
Risk R36/37/38
Safety
Hazard Codes of Sertraline (CAS NO.79617-96-2): Xi
Risk Statements:
36:?Irritating to the eyes
37:?Irritating to the respiratory system
38:?Irritating to the skin
Safety Statements:
26:?In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:?Wear suitable protective clothing
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| man |
TDLo |
oral |
5714ug/kg/9D- (5.714mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: EXCITEMENT |
Journal of Clinical Psychiatry. Vol. 55, Pg. 316, 1994. |
| man |
TDLo |
oral |
3571mg/kg/5D- (3571mg/kg) |
ENDOCRINE: ANTIDIURESIS |
American Journal of Psychiatry. Vol. 152, Pg. 809, 1995. |
| women |
TDLo |
oral |
2mg/kg/2D-I (2mg/kg) |
BEHAVIORAL: EXCITEMENT |
Journal of the American Academy of Child and Adolescent Psychiatry. Vol. 35, Pg. 975, 1996. |
| women |
TDLo |
oral |
6mg/kg/4D-I (6mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
ENDOCRINE: ANTIDIURESIS |
American Journal of Psychiatry. Vol. 152, Pg. 809, 1995. |
| women |
TDLo |
oral |
10500ug/kg/3W (10.5mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
ENDOCRINE: ANTIDIURESIS |
Annals of Internal Medicine. Vol. 123, Pg. 811, 1995. |
| women |
TDLo |
oral |
28mg/kg/4W-I (28mg/kg) |
BLOOD: AGRANULOCYTOSIS |
Postgraduate Medical Journal. Vol. 72, Pg. 446, 1996. |
| women |
TDLo |
oral |
63mg/kg/10W-I (63mg/kg) |
BLOOD: TUMORS |
American Journal of Psychiatry. Vol. 153, Pg. 443, 1996. |
| women |
TDLo |
oral |
70mg/kg/7W-I (70mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
American Journal of Psychiatry. Vol. 153, Pg. 732, 1996. |
