Simvastatin cas no:79902-63-9
Synonyms: Butanoic acid,2,2-dimethyl-,(1S,3R,7S,8S,- 8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8- [2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo- 2H-pyran-2-yl]ethyl]-1-naphthalenyl ester;Colemin;Nivelipol;Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta))-;Simvastatin [USAN:BAN:INN];Velostatin;Coledis;MK-733;Medipo;MK 0733;Simvastatin (COS);MK-0733;Labistatin;Simvastatine [French];Zocor (TN);(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate;Sivastin;Rendapid;Synvinolin;Corolin;Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester;Liponorm;Lodales;Pantok;[(1S,3R,7R,8S,8aR)-8-[2-[(4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate;Lipex;Vasotenal;
NameSimvastatin
CAS79902-63-9
SynonymsButanoic acid,2,2-dimethyl-,(1S,3R,7S,8S,- 8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8- [2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo- 2H-pyran-2-yl]ethyl]-1-naphthalenyl ester;Colemin;Nivelipol;Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta))-;Simvastatin [USAN:BAN:INN];Velostatin;Coledis;MK-733;Medipo;MK 0733;Simvastatin (COS);MK-0733;Labistatin;Simvastatine [French];Zocor (TN);(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate;Sivastin;Rendapid;Synvinolin;Corolin;Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester;Liponorm;Lodales;Pantok;[(1S,3R,7R,8S,8aR)-8-[2-[(4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate;Lipex;Vasotenal;
EINECS(EC#)404-520-2
Molecular FormulaC25H38O5
Molecular Weight418.57
Appearancewhite to off- white crystalline powder
refractive index1.53
storage temp0-6°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass9
Hazard Xi: Irritant;
Risk R36/37/38
Safety
Safty information about Simvastatin (CAS NO.79902-63-9) is:
Hazard Codes:?
Xi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
RIDADR: 3077
RTECS: EK7798000
HazardClass: 9
PackingGroup: III
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
oral |
> 5gm/kg (5000mg/kg) |
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
GASTROINTESTINAL: NAUSEA OR VOMITING |
Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990. |
| mouse |
LD50 |
intraperitoneal |
798mg/kg (798mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) |
Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990. |
| mouse |
LD50 |
oral |
3gm/kg (3000mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: OTHER CHANGES |
Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990. |
| mouse |
LD50 |
subcutaneous |
1009mg/kg (1009mg/kg) |
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) |
Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990. |
| rat |
LD50 |
intraperitoneal |
705mg/kg (705mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) |
Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990. |
| rat |
LD50 |
oral |
4438mg/kg (4438mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: OTHER CHANGES |
Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990. |
| rat |
LD50 |
subcutaneous |
672mg/kg (672mg/kg) |
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) |
Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 95, 1990. |
| women |
LDLo |
oral |
108mg/kg/77W- (108mg/kg) |
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Australian and New Zealand Journal of Medicine. Vol. 25, Pg. 745, 1995. |
| women |
TDLo |
oral |
2800ug/kg/7D- (2.8mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LIVER: LIVER FUNCTION TESTS IMPAIRED |
Medical Journal of Australia. Vol. 155, Pg. 61, 1991. |
