8-Azoniabicyclo[3.2.1]octane,3-[(2-hydroxy-2-phenylacetyl)oxy]-8,8-dimethyl-, bromide (1:1), (3-endo)- cas no:80-49-9
Synonyms: 1aH,5aH-Tropanium, 3a-hydroxy-8-methyl-, bromide, mandelate (8CI);8-Methylhomatropinium bromide(6CI,7CI);Camatropine;Helbatropin;Homatrocel;Homatropil;Homolone;Mesopin;Methatropine;Methylhomatropinehydrobromide;NSC 34399;Novatrine;Novatropine;Sethyl;
Name8-Azoniabicyclo[3.2.1]octane,3-[(2-hydroxy-2-phenylacetyl)oxy]-8,8-dimethyl-, bromide (1:1), (3-endo)-
CAS80-49-9
Synonyms1aH,5aH-Tropanium, 3a-hydroxy-8-methyl-, bromide, mandelate (8CI);8-Methylhomatropinium bromide(6CI,7CI);Camatropine;Helbatropin;Homatrocel;Homatropil;Homolone;Mesopin;Methatropine;Methylhomatropinehydrobromide;NSC 34399;Novatrine;Novatropine;Sethyl;
EINECS(EC#)201-284-0
Molecular FormulaC17H24NO3.Br
Molecular Weight370.28
refractive index1.588
Risk R20/21/22
Safety
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. An anticholinergic agent. An FDA over-the-counter and proprietary drug. When heated to decomposition it emits very toxic fumes of Br− and NOx.
Risk Statements: 20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-26-36
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR: 1544
RTECS: MS9000000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| guinea pig |
LD50 |
intraperitoneal |
120mg/kg (120mg/kg) |
|
Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 166, 1952. |
| guinea pig |
LD50 |
oral |
1gm/kg (1000mg/kg) |
|
Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 166, 1952. |
| guinea pig |
LD50 |
subcutaneous |
75mg/kg (75mg/kg) |
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962. |
| mouse |
LD50 |
intraperitoneal |
60mg/kg (60mg/kg) |
|
Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 166, 1952. |
| mouse |
LD50 |
oral |
1400mg/kg (1400mg/kg) |
|
Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 166, 1952. |
| mouse |
LD50 |
subcutaneous |
130mg/kg (130mg/kg) |
|
French Demande Patent Document. Vol. #2035763, |
| rat |
LD50 |
intraperitoneal |
82mg/kg (82mg/kg) |
|
Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 166, 1952. |
| rat |
LD50 |
intravenous |
12mg/kg (12mg/kg) |
|
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 236, Pg. 149, 1959. |
| rat |
LD50 |
oral |
1200mg/kg (1200mg/kg) |
|
Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 166, 1952. |
| rat |
LD50 |
subcutaneous |
800mg/kg (800mg/kg) |
|
Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 166, 1952. |
