Pregnane-3,20-diol, (3α,5β,20S) cas no:80-92-2

NamePregnane-3,20-diol, (3α,5β,20S)
CAS80-92-2
Synonyms5β-Pregnane-3α,20α-diol (8CI);Diol (6CI,7CI);3α,20α-Dihydroxy-5β-pregnane;NSC 1612;NSC 47462;
EINECS(EC#)201-313-7
Molecular FormulaC₂₁H₃₆O₂
Molecular Weight320.51

Appearancewhite solid
refractive index1.531
storage temp-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TU4157113

CHEMICAL NAME :

5-beta-Pregnane-3-alpha, 20-alpha-diol

CAS REGISTRY NUMBER :

80-92-2

BEILSTEIN REFERENCE NO. :

3083715

LAST UPDATED :

199709

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C21-H36-O2

MOLECULAR WEIGHT :

320.57

WISWESSER LINE NOTATION :

L E5 B666TJ A1 E1 FYQ1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>40 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :

JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,709,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,709,1982

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

7 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :

JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968