Safety
Mildly toxic by ingestion. A centrally acting emetic. Human systemic effects by ingestion: nausea, vomiting, blood pressure lowering, change in heart rate, dyspnea. Has caused fatalities after prolonged ingestion. An FDA over-the-counter drug. See also EMETINE.
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | oral | 5gm/kg (5000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: NAUSEA OR VOMITING |
"Management of the Poisoned Patient," Rumack, B.H., and A.R. Temple, eds., Princeton, NJ, Science Press, 1977Vol. -, Pg. 175, 1977. |
| human | TDLo | oral | 70mg/kg (70mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pharmaceutical Sciences. Vol. 65, Pg. 1398, 1976. |
| man | TDLo | oral | 214mg/kg (214mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: NAUSEA OR VOMITING |
Southern Medical Journal. Vol. 77, Pg. 804, 1984. |
| rat | LDLo | oral | 510uL/kg (0.51mL/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 27, Pg. 891, 1999. |
| women | LDLo | oral | 113mg/kg/13W- (113mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: CHANGE IN RATE LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
JAMA, Journal of the American Medical Association. Vol. 243, Pg. 1927, 1980. |
Home | About Us | Service | Links | Add to Favorite
Copyright©2011 HiIntermediates ICP: B2-20090288 浙ICP备09045134号-49