Roxithromycin cas no:80214-83-1
Synonyms: Roxithromycin，Stearyl Glycyrrhetinate;Roxithromycin EP;RU 965;Rulide (TN);Roxithromycinum [Latin];RU 28965;9-(O-((2-Methoxyethoxy)methyl)oxime)erythromycin;Roxithromycin (JP14/USAN);Roxithromycine [French];(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one;Roxitromicina [Spanish];Rulide;Prestwick_1046;Erythromycin, 9-(O-((2-methoxyethoxy)methyl)oxime), (9E)-;
NameRoxithromycin
CAS80214-83-1
SynonymsRoxithromycin，Stearyl Glycyrrhetinate;Roxithromycin EP;RU 965;Rulide (TN);Roxithromycinum [Latin];RU 28965;9-(O-((2-Methoxyethoxy)methyl)oxime)erythromycin;Roxithromycin (JP14/USAN);Roxithromycine [French];(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one;Roxitromicina [Spanish];Rulide;Prestwick_1046;Erythromycin, 9-(O-((2-methoxyethoxy)methyl)oxime), (9E)-;
Molecular FormulaC41H76N2O15
Molecular Weight837.05
Appearancewhite crystalline powder
refractive index1.535
storage temp2-8°C
Hazard Xn:Harmful
Risk R22
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KF4990000
- CHEMICAL NAME :
- Erythromycin, 9-O-((2-methoxyethoxy)methyl)oxime
- CAS REGISTRY NUMBER :
- 80214-83-1
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C41-H76-N2-O15
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 830 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
36(Suppl 4),94,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 665 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1471,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- .2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1471,1995
