Toxins, curare cas no:8063-06-7

NameToxins, curare
CAS8063-06-7
SynonymsCurare;Curare-like substances; Arrow poisons; Calabash curare; Calabash curare,intocostrin; Curare, intocostrin; Intocostrin; Intocostrin curare;Intocostrine; Poisons, curare
EINECS(EC#)232-511-1
Molecular FormulaC39H46N2O5+2
Molecular Weight0

Safety

A deadly human poison by an unspecified route. A deadly experimental poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits highly toxic fumes.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	1200ug/kg (1.2mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 82, Pg. 266, 1944.
man	LDLo	unreported	735ug/kg (0.735mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	intraperitoneal	3200ug/kg (3.2mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 308, 1965.
mouse	LD50	intravenous	140ug/kg (0.14mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 118, Pg. 756, 1965.
mouse	LD50	subcutaneous	500ug/kg (0.5mg/kg)		Naturwissenschaften. Vol. 56, Pg. 615, 1969.
rabbit	LD50	intravenous	1300ug/kg (1.3mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 82, Pg. 266, 1944.
rabbit	LDLo	oral	270mg/kg (270mg/kg)		Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 61, Pg. 283, 1909.
rabbit	LDLo	subcutaneous	2700ug/kg (2.7mg/kg)		Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 61, Pg. 283, 1909.