Clarithromycin cas no:81103-11-9
Synonyms: Adel;Mabicrol;TE 031;Klaricid;Biaxin (TN);(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-6-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-14-ethyl-12,13-dihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione;Clarithromycine [INN-French];Clacine;Trovafloxacin & Clarithromycin;6-o-Methoxyerythromycin;(3R,4S,6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione;Abbott-56268;Clarith;Klacid;Claritromicina [INN-Spanish];Klaciped;6-O-Methylerythromycin A;Kofron;Heliclar;Klarin;TE-031;TE031;Maclar;Klaricid Pediatric;Biaxin;(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione;Helas;Veclam;Klarid;Clathromycin;Zeclar;Clarithromycinum [INN-Latin];Claribid;Klax;Mavid;
NameClarithromycin
CAS81103-11-9
SynonymsAdel;Mabicrol;TE 031;Klaricid;Biaxin (TN);(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-6-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-14-ethyl-12,13-dihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione;Clarithromycine [INN-French];Clacine;Trovafloxacin & Clarithromycin;6-o-Methoxyerythromycin;(3R,4S,6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione;Abbott-56268;Clarith;Klacid;Claritromicina [INN-Spanish];Klaciped;6-O-Methylerythromycin A;Kofron;Heliclar;Klarin;TE-031;TE031;Maclar;Klaricid Pediatric;Biaxin;(3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione;Helas;Veclam;Klarid;Clathromycin;Zeclar;Clarithromycinum [INN-Latin];Claribid;Klax;Mavid;
Molecular FormulaC38H69NO13
Molecular Weight747.95336
Appearancewhite to off-white crystalline powder
refractive index-92 ° (C=1, CHCl3)
storage tempStore only in original container. Keep container tightly closed.
Hazard Xi: Irritant;Xn: Harmful;
Risk R22
Safety
A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Human systemic effects. When heated to decomposition it emits toxic vapors of NOx.
Hazard Codes: 
Xn,
Xi
Risk Statements: 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RTECS: KF4997000
HS Code 29419000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD |
oral |
> 5gm/kg (5000mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: HEMORRHAGE |
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 1453, 1988. |
| mouse |
LD50 |
intraperitoneal |
850mg/kg (850mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Chemotherapy Vol. 36(Suppl, |
| mouse |
LD50 |
intravenous |
173mg/kg (173mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991. |
| mouse |
LD50 |
oral |
1230mg/kg (1230mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 1433, 1988. |
| mouse |
LD50 |
subcutaneous |
> 5gm/kg (5000mg/kg) |
SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE |
Chemotherapy Vol. 36(Suppl, |
| rat |
LD50 |
intraperitoneal |
669mg/kg (669mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Chemotherapy Vol. 36(Suppl, |
| rat |
LD50 |
oral |
1270mg/kg (1270mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 1433, 1988. |
| rat |
LD50 |
subcutaneous |
> 5gm/kg (5000mg/kg) |
SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE |
Chemotherapy Vol. 36(Suppl, |
| women |
TDLo |
oral |
30mg/kg/3D-I (30mg/kg) |
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
CARDIAC: CHANGE IN RATE |
Annals of Emergency Medicine. Vol. 30, Pg. 542, 1997. |
