81486-22-8|2H-1-Benzopyran-3-ol,3,4-dihydro-8-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, 3-nitrateProducts Supply

2H-1-Benzopyran-3-ol,3,4-dihydro-8-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, 3-nitrate cas no:81486-22-8

Synonyms: Hypadil; K351; KT 210; Nipradilol; Nipradolol

Identification

Name2H-1-Benzopyran-3-ol,3,4-dihydro-8-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, 3-nitrate
CAS81486-22-8
SynonymsHypadil; K351; KT 210; Nipradilol; Nipradolol
Molecular FormulaC15H22 N2 O6
Molecular Weight326.39

Chemical Properties

AppearanceColorless needle crystal
refractive index1.561

Safety Data

Safety

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. When Nipradilol (CAS NO.81486-22-8) is heated to decomposition ,it emits toxic fumes of NO_x. See also NITRATES.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	20mg/kg (20mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
dog	LD50	oral	> 400mg/kg (400mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
mouse	LD50	intraperitoneal	147mg/kg (147mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
mouse	LD50	intravenous	68mg/kg (68mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
mouse	LD50	oral	461mg/kg (461mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
mouse	LD50	subcutaneous	416mg/kg (416mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
rabbit	LD50	intravenous	20mg/kg (20mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
rabbit	LD50	oral	300mg/kg (300mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
rat	LD50	intraperitoneal	144mg/kg (144mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
rat	LD50	intravenous	78mg/kg (78mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
rat	LD50	oral	1040mg/kg (1040mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
rat	LD50	subcutaneous	850mg/kg (850mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.

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2H-1-Benzopyran-3-ol,3,4-dihydro-8-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, 3-nitrate cas no:81486-22-8

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