82159-09-9|EpalrestatProducts Supply - Chemical intermediates Network

Epalrestat cas no:82159-09-9

Synonyms: 2-[(5Z)-5-[(E)-2-methyl-3-phenyl-prop-2-enylidene]-4-oxo-2-sulfanylidene-thiazolidin-3-yl]acetic acid;3-Thiazolidineacetic acid,5-[(2E)-2-methyl-3-phenyl-2-propenylidene]- 4-oxo-2-thioxo-,(5Z)-;3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-;Kinedak;Epalrestat (JAN);5-((Z,E)-beta-Methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid;Epalrestat [INN];Kinedak (TN);Ono 2235;Epalrestatum [Latin];Properties: orange red crystalline powder, with special odor;Epalrestate;Epatrestat;

Identification

NameEpalrestat
CAS82159-09-9
Synonyms2-[(5Z)-5-[(E)-2-methyl-3-phenyl-prop-2-enylidene]-4-oxo-2-sulfanylidene-thiazolidin-3-yl]acetic acid;3-Thiazolidineacetic acid,5-[(2E)-2-methyl-3-phenyl-2-propenylidene]- 4-oxo-2-thioxo-,(5Z)-;3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-;Kinedak;Epalrestat (JAN);5-((Z,E)-beta-Methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid;Epalrestat [INN];Kinedak (TN);Ono 2235;Epalrestatum [Latin];Properties: orange red crystalline powder, with special odor;Epalrestate;Epatrestat;
Molecular FormulaC₁₅H₁₃NO₃S₂
Molecular Weight319.39862

Chemical Properties

AppearanceDeep red acicular crystal
refractive index1.705
storage tempStore in original container in a cool dark place.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 1gm/kg (1000mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse	LD50	intraperitoneal	687mg/kg (687mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse	LD50	intravenous	255ug/kg (0.255mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse	LD50	oral	3200mg/kg (3200mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse	LD50	subcutaneous	> 3gm/kg (3000mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat	LD50	intraperitoneal	922gm/kg (922000mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat	LD50	intravenous	255ug/kg (0.255mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat	LD50	oral	5300ug/kg (5.3mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat	LD50	subcutaneous	> 3gm/kg (3000mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.

supplier list

Hangzhou Hysen Pharma Co., Ltd: Tel:; Address: No.808, B Building,Zijin Plaza, No.701,Gudun ROAD,Hangzhou

Tomson Chemical Co., Ltd.: Tel:; Address: 23rd FLOOR, GUODU DEVELOPING BUILDING, No238, ZHAOHUI ROAD, HANGZHOU, CHINA

KOA SHOJI CO., LTD.: Tel:+81-45-540-6985; Address: 17-5, Minowa-cho, 2-chome, Kohoku-ku, Yokohama-shi, Kanagawa, 223-0051, Japan

Shanghai Entropy Chemical Co., Ltd.: Tel:+86-(21)-5512-2488; Address: Fengxian District, Shanghai 201400,

Hetero Drugs Ltd.,: Tel:+91-(40)-23704923; Address: H.No. 8-3-166/7/1, Erragadda, Hyderabad, Andhra Pradesh 500 018,

Cangzhou Goldlion Chemicals Co., Ltd.: Tel:+86-(317)-3200188; Address: 402-1, No.5th Building, Chaoyang Huayuan Area ,NO.32, Yuhe Road ,Cangzhou City, Hebei Province, PRC, Cangzhou, Hebei 061001,

Taizhou Creating Chemical Co. ,Ltd.: Tel:+86-(576)-88827176,88820069; Address: B Suite 12F,JiangbinBuilding,Jiaojiang, Taizhou, Zhejiang,

Shanghai Chely Co. Ltd.: Tel:021- 68885110; Address: #603，Block7，Rongcheng Garden，#9 Rongcheng, Pudong, Shanghai 200120,

Cangzhou Senary Chemical Science-Tech Co., Ltd.: Tel:+86-(317)-3563899, 3563699; Address: 168 Jinde Road, Cangzhou, Hebei 061000,

Changzhou VX Chemicals Co., Ltd.: Tel:+86-(519)-86011997; Address: No.5 Binjiang Road, Jiangbian Chemical Park, Xinbei District, Changzhou, Jiangsu 213033,

Haorui Pharma-Chem Inc.: Tel:+1-(732)-906-7666; Address: 100 Menlo Park Dr, Suite 316, Edison, New Jersey 08837-242,

APAC Pharmaceutical, LLC: Tel:+1-(410)-997-5552, 469-0727; Address: 6851 Oak Hall Lane, Suite 101, Columbia, Maryland 21045,

Tecoland Corporation: Tel:+1-(732)-603-9577; Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428,

Wuhan Borui Fine Chemical Co., Ltd.: Tel:+86-(27)-8355-0361; Address: No.448 Jinghan Road, QiaoKou, Wuhan, Hubei 430022,

Jiangxi Taisinor Co., Ltd.: Tel:+86-(791)-2108811, 2108833, 2061117; Address: Qinghua Science Park No.299,Economy-Tech Eevelopment Zone, Nanchang, Jiangsu 330013,

Epalrestat cas no:82159-09-9

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