82410-32-0|GanciclovirProducts Supply - Chemical intermediates Network

Ganciclovir cas no:82410-32-0

Synonyms: 2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; 2'-NDG; 2'-Nor-2'-deoxyguanosine

Identification

NameGanciclovir
CAS82410-32-0
Synonyms2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; 2'-NDG; 2'-Nor-2'-deoxyguanosine
Molecular FormulaC₉H₁₃N₅O₄
Molecular Weight255.23062

Chemical Properties

Appearancewhite powder
storage temp2-8°C

Safety Data

Hazard T:Toxic
Risk R46;R60;R61
Safety

Common adverse drug reactions >=1% of patients) include: neutropenia, granulocytopenia, thrombocytopenia, fever, nausea, vomiting, dyspepsia, diarrhoea, abdominal pain, flatulence, anorexia, raised liver enzymes, headache, confusion, hallucination, anaemia, pain and phlebitis at injection site (due to high pH), sweating, rash.
Hazard Codes:? Toxic T
Risk Statements: 46-60-61?
R46:May cause heritable genetic damage.?
R60:May impair fertility.?
R61:May cause harm to the unborn child.
Safety Statements: 53-36/37/39-45?
S53:Avoid exposure - obtain special instructions before use.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS of Ganciclovir (CAS NO.82410-32-0): MF8407000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	> 150mg/kg (150mg/kg)	?	Drugs in Japan Vol. -, Pg. 291, 1990.
dog	LD50	oral	> 1gm/kg (1000mg/kg)	?	Drugs in Japan Vol. -, Pg. 291, 1990.
mouse	LD50	intraperitoneal	1gm/kg (1000mg/kg)	?	Journal of Medicinal Chemistry. Vol. 26, Pg. 759, 1983.
mouse	LD50	intravenous	900mg/kg (900mg/kg)	?	Drugs in Japan Vol. -, Pg. 291, 1990.
mouse	LD50	oral	> 2gm/kg (2000mg/kg)	?	Drugs in Japan Vol. -, Pg. 291, 1990.

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Ganciclovir cas no:82410-32-0

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