1H-Indene-1,3(2H)-dione,2-phenyl- cas no:83-12-5

Name1H-Indene-1,3(2H)-dione,2-phenyl-
CAS83-12-5
Synonyms1,3-Indandione,2-phenyl- (6CI,8CI); 2-Phenyl-1,3-diketohydrindene; 2-Phenyl-1,3-indandione;2-Phenyl-1,3-indanedione; 2-Phenyl-1H-indene-1,3(2H)-dione; 2-Phenylindandione;Athrombon; Bindan; Cronodione; Danedion; Danilon; Danilone; Diadilan; Dindevan;Dineval; Diophindane; Emandion; Emandione; Fenhydren; Fenilin; Fenindion;Hedulin; Hemolidione; Indema; Indion; Indon; NSC 41693; PID; Phenhydren;Phenillin; Phenindione; Phenylen; Phenylin; Phenylindione; Pindione;Rectadione; Theradione; Thrombasal; Tromazal; Trombol
EINECS(EC#)201-454-4
Molecular FormulaC15H10 O2
Molecular Weight222.25

refractive index1.703

Hazardclass6.1(b)

Hazard T: Toxic;
Risk R25
Safety

A human poison by ingestion. Poison experimentally by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Human systemic effects by: blood effects, fever, hepatitis, hepatocellular necrosis, dermatitis, allergic effects, other skin effects, nausea or vomiting, tubule changes, urine volume decrease, interstitial nephritis. When heated to decomposition it emits acrid smoke and irritating fumes. Used to treat angina pectoris.
Hazard Codes T
Risk Statements 25
R25 :Toxic if swallowed.
Safety Statements 36/37/39-45
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS NK6125000
HazardClass 6.1(b)
PackingGroup III

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	LDLo	oral	48mg/kg/27D-I (48mg/kg)	BLOOD: OTHER CHANGES	New Zealand Medical Journal. Vol. 57, Pg. 283, 1958.
man	LDLo	unreported	1683mg/kg/31D (1683mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Lancet. Vol. 1, Pg. 920, 1963.
man	TDLo	oral	42500ug/kg/17 (42.5mg/kg)	KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	British Medical Journal. Vol. 1, Pg. 1655, 1963.
man	TDLo	unreported	22mg/kg/17D-I (22mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Annals of Internal Medicine. Vol. 52, Pg. 706, 1960.
man	TDLo	unreported	90mg/kg/27D-I (90mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	Canadian Medical Association Journal. Vol. 77, Pg. 1028, 1957.
mouse	LD50	intraperitoneal	150mg/kg (150mg/kg)		Pharmazie. Vol. 27, Pg. 520, 1972.
mouse	LD50	intravenous	130mg/kg (130mg/kg)	BEHAVIORAL: REGIDITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Therapie. Vol. 16, Pg. 34, 1961.
mouse	LD50	oral	175mg/kg (175mg/kg)		Schweizerische Medizinische Wochenschrift. Vol. 90, Pg. 213, 1960.
mouse	LD50	subcutaneous	140mg/kg (140mg/kg)		Dissertationes Pharmaceuticae. Vol. 8, Pg. 289, 1956.
rat	LD50	intraperitoneal	190mg/kg (190mg/kg)	BEHAVIORAL: REGIDITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Therapie. Vol. 16, Pg. 34, 1961.
rat	LD50	oral	163mg/kg (163mg/kg)		European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 519, 1974.