Pregna-1,4-diene-3,20-dione,11,17,21-trihydroxy-6-methyl-, (6a,11b)- cas no:83-43-2
Synonyms: Pregna-1,4-diene-3,20-dione,11b,17,21-trihydroxy-6a-methyl- (7CI,8CI);11b,17,21-Trihydroxy-6a-methylpregna-1,4-diene-3,20-dione;6a-Methyl-11b,17a,21b-trihydroxy-1,4-pregnadiene-3,20-dione;6a-Methylprednisolone;Besonia;Duralone;M-Prednisol;Medorol;Medralone;Medrol;Metastab;Methylprednisolone;Metilbetasone;Metrisone;NSC 19987;Prednol;Promacortine;Suprametil;Urbason;Urbasone;Wyacort;Methylphenisolone;
NamePregna-1,4-diene-3,20-dione,11,17,21-trihydroxy-6-methyl-, (6a,11b)-
CAS83-43-2
SynonymsPregna-1,4-diene-3,20-dione,11b,17,21-trihydroxy-6a-methyl- (7CI,8CI);11b,17,21-Trihydroxy-6a-methylpregna-1,4-diene-3,20-dione;6a-Methyl-11b,17a,21b-trihydroxy-1,4-pregnadiene-3,20-dione;6a-Methylprednisolone;Besonia;Duralone;M-Prednisol;Medorol;Medralone;Medrol;Metastab;Methylprednisolone;Metilbetasone;Metrisone;NSC 19987;Prednol;Promacortine;Suprametil;Urbason;Urbasone;Wyacort;Methylphenisolone;
EINECS(EC#)201-476-4
Molecular FormulaC22H30O5
Molecular Weight374.48
Appearancewhite to off-white crystalline powder
refractive index82 ° (C=1, Dioxane)
storage temp0-6°C
Hazard Xi
Risk R36/37/38
Safety Moderately toxic by intraperitoneal route. A steroid hormone. Human systemic effects include arrhythmias, blood pressure lowering, heart rate changes, increased body temperature, pulse rate increase, respiratory depression. When heated to decomposition it emits acrid smoke and irritating fumes.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU4146000
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione,
6-alpha-methyl-11-beta-17,21-trihydroxy-
- CAS REGISTRY NUMBER :
- 83-43-2
- BEILSTEIN REFERENCE NO. :
- 2340300
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C22-H30-O5
- MOLECULAR WEIGHT :
- 374.52
- WISWESSER LINE NOTATION :
- L E5 B666 OV AHTTT&J A1 CQ E1 FV1Q FQ L1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 2400 ug/kg
- TOXIC EFFECTS :
- Cardiac - change in rate
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year:
69,422,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 60 mg/kg/3D-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP
Vascular - BP lowering not characterized in autonomic section
Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
99,282,1983
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 20 mg/kg/45M-C
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont.,
Canada) V.1- 1974- Volume(issue)/page/year: 13,477,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,832,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2292 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,832,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 210 mg/kg/6W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - changes in sodium
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
1,305,1959
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84067
No. of Facilities: 33 (estimated)
No. of Industries: 2
No. of Occupations: 1
No. of Employees: 272 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84067
No. of Facilities: 42 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 2047 (estimated)
No. of Female Employees: 983 (estimated)
