1H-Purine-2,6-dione,3,7-dihydro-3,7-dimethyl- cas no:83-67-0
Synonyms: Theobromine(8CI);3,7-Dimethyl-3,7-dihydro-1H-purine-2,6-dione;3,7-Dimethylxanthine;Diurobromine;NSC 5039;SC 15090;Santheose;Teobromin;Theosalvose;Theostene;Thesal;
Name1H-Purine-2,6-dione,3,7-dihydro-3,7-dimethyl-
CAS83-67-0
SynonymsTheobromine(8CI);3,7-Dimethyl-3,7-dihydro-1H-purine-2,6-dione;3,7-Dimethylxanthine;Diurobromine;NSC 5039;SC 15090;Santheose;Teobromin;Theosalvose;Theostene;Thesal;
EINECS(EC#)201-494-2
Molecular FormulaC7H8N4O2
Molecular Weight180.16
Appearancewhite to yellow crystalline powder
refractive index1.737
storage tempKeep container closed when not in use. Store in a cool, dry area away from incompatible substances.
Hazard Xn:Harmful;
Risk R22
Safety
Hazard Symbols: Xn .gif)
Risk Codes : 22
22: Theobromine (83-67-0) is harmful if swallowed
Safety Description : 22-24/25
22: Do not breathe dust
24/25: Avoid contact with skin and eyes
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Organism
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Test Type
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Route
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Reported Dose (Normalized Dose)
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Effect
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Source
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cat
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LD50
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oral
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200mg/kg (200mg/kg)
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1372, 1986.
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dog
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LD50
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oral
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300mg/kg (300mg/kg)
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Toxicology and Applied Pharmacology. Vol. 53, Pg. 481, 1980.
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human
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TDLo
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oral
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26mg/kg (26mg/kg)
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behavioral: changes in motor activity (specific assay)
gastrointestinal: nausea or vomiting
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Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 113, 1946.
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mouse
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LD50
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intraperitoneal
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552mg/kg (552mg/kg)
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behavioral: convulsions or effect on seizure threshold
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Acta Pharmaceutica Vol. 46, Pg. 93, 1996.
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mouse
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LD50
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oral
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837mg/kg (837mg/kg)
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Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(3), Pg. 59, 1982.
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mouse
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LD50
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subcutaneous
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530mg/kg (530mg/kg)
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Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 601, 1956.
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rabbit
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LDLo
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subcutaneous
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1gm/kg (1000mg/kg)
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"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
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rat
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LD50
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oral
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1265mg/kg (1265mg/kg)
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Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(3), Pg. 59, 1982.
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