83-79-4|RotenoneProducts Supply - Chemical intermediates Network

Rotenone cas no:83-79-4

Synonyms: (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno(3,4-b)furo(2,3-h)chromen-6-one; tubatoxin

Identification

NameRotenone
CAS83-79-4
Synonyms(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno(3,4-b)furo(2,3-h)chromen-6-one; tubatoxin
EINECS(EC#)201-501-9
Molecular FormulaC23H22O6
Molecular Weight394.42

Chemical Properties

Appearancewhite or off-white powder
alpha-115 º (C=1.4 IN CHLOROFORM)
refractive index1.591
storage tempStore at RT

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard T:Toxic;N:Dangerousfortheenvironment;
Risk R25;R36/37/38;R50/53
Safety

Hazard Codes of Rotenone (CAS NO.83-79-4): Toxic T, Dangerous N
Risk Statements: 25-36/37/38-50/53
R25: Toxic if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 22-24/25-36-45-60-61
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S36: Wear suitable protective clothing.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60: This material and its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DJ2800000
HazardClass: 6.1(b)
PackingGroup: III
Human poison by ingestion. Experimental poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. A skin and eye irritant. Acute poisoning causes numbness, nausea, vomiting, and tremors. Questionable carcinogen with experimental neoplastigenic, tumorigenic, and teratogenic data. Chronic exposure injures liver and kidneys. It is toxic to animals and very toxic to fish, but leaves no harmful residue on vegetable crops. When heated to decomposition it emits acrid smoke and irritating fumes. Used as an insecticide and as a fish poison.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	650ug/kg (0.65mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 193, 1931.
dog	LDLo	intravenous	650ug/kg (0.65mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 193, 1931.
dog	LDLo	oral	300mg/kg (300mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 193, 1931.
duck	LD50	oral	> 2gm/kg (2000mg/kg)		Down to Earth. Vol. 35, Pg. 25, 1979.
frog	LDLo	oral	4mg/kg (4mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 193, 1931.
guinea pig	LDLo	intraperitoneal	10mg/kg (10mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Proceedings of the Society for Experimental Biology and Medicine. Vol. 34, Pg. 135, 1936.
guinea pig	LDLo	oral	100mg/kg (100mg/kg)	LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Proceedings of the Society for Experimental Biology and Medicine. Vol. 34, Pg. 135, 1936.
human	LDLo	oral	143mg/kg (143mg/kg)	GASTROINTESTINAL: OTHER CHANGES	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 521, 1969.
man	LDLo	unreported	294mg/kg (294mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	intraperitoneal	2650ug/kg (2.65mg/kg)		Radiation Research. Vol. 91, Pg. 186, 1982.
mouse	LD50	oral	2800ug/kg (2.8mg/kg)		EHP, Environmental Health Perspectives. Vol. 14, Pg. 109, 1976.
pig	LDLo	oral	3700ug/kg (3.7mg/kg)	BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of the American Veterinary Medical Association. Vol. 130, Pg. 410, 1957.
pigeon	LDLo	intravenous	1mg/kg (1mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 193, 1931.
rabbit	LD50	skin	> 1gm/kg (1000mg/kg)		Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 5, 1978.
rabbit	LDLo	intramuscular	5mg/kg (5mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 193, 1931.
rabbit	LDLo	intravenous	350ug/kg (0.35mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 193, 1931.
rabbit	LDLo	oral	1600mg/kg (1600mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 193, 1931.
rabbit	LDLo	subcutaneous	20mg/kg (20mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 193, 1931.
rat	LCLo	inhalation	500mg/m3/30M (500mg/m3)		Farmaco, Edizione Scientifica. Vol. 20, Pg. 270, 1965.
rat	LD50	intraperitoneal	1600ug/kg (1.6mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: COMA	Farmaco, Edizione Scientifica. Vol. 20, Pg. 270, 1965.
rat	LD50	intravenous	200ug/kg (0.2mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Farmaco, Edizione Scientifica. Vol. 20, Pg. 270, 1965.
rat	LD50	oral	60mg/kg (60mg/kg)		Down to Earth. Vol. 35, Pg. 25, 1979.
rat	LD50	skin	> 940mg/kg (940mg/kg)		World Review of Pest Control. Vol. 9, Pg. 119, 1970.
rat	LD50	unreported	132mg/kg (132mg/kg)		Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. Vol. 15, Pg. 929, 1980.

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