Ethanamine,N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]- cas no:83-98-7

NameEthanamine,N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-
CAS83-98-7
SynonymsEthylamine,N,N-dimethyl-2-[(o-methyl-a-phenylbenzyl)oxy]- (8CI); (?à)-Orphenadrine; 2-Methyldiphenhydramine; BS 5930; Biorphen; Brocadisipal;N,N-Dimethyl-2-(o-methyl-a-phenylbenzyloxy)ethylamine; N,N-Dimethyl-N-[2-(o-methyl-a-phenylbenzyloxy)ethyl]amine;ORP; Orphenadine; Orphenadrin; Orphenadrine; Phenyl-o-tolylmethyldimethylaminoethyl ether; WS 2434; o-Methyldiphenhydramine
EINECS(EC#)201-509-2
Molecular FormulaC18H23 N O
Molecular Weight269.42

Hazardclass6.1(b)

Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: convulsions, coma, arrhythmias, pulse rate increase and blood pressure elevation. When heated to decomposition it emits toxic fumes of NO_x. See also AMINES.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	14mg/kg (14mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Acta Pharmacologica et Toxicologica, Supplementun. Vol. 41(2), Pg. 137, 1977.
human	TDLo	oral	7143mg/kg (7143mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Archives of Toxicology, Supplement. Vol. 4, Pg. 425, 1980.
mouse	LD50	intraperitoneal	80mg/kg (80mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 62, 1962.
mouse	LD50	intravenous	33mg/kg (33mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 62, 1962.
mouse	LD50	oral	125mg/kg (125mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 62, 1962.
mouse	LD50	subcutaneous	150mg/kg (150mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 62, 1962.