mouse |
LD50 |
intraperitoneal |
164mg/kg (164mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl, |
mouse |
LD50 |
oral |
3120mg/kg (3120mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl, |
mouse |
LD50 |
subcutaneous |
2340mg/kg (2340mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl, |
rat |
LD50 |
intraperitoneal |
208mg/kg (208mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl, |
rat |
LD50 |
oral |
8260mg/kg (8260mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl, |
rat |
LD50 |
subcutaneous |
5900mg/kg (5900mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl, |