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Phenol,4,4'-[(1R,2S)-1,2-diethyl-1,2-ethanediyl]bis-, rel- cas no:84-16-2

Synonyms: Phenol,4,4'-(1,2-diethyl-1,2-ethanediyl)bis-, (R*,S*)-; Phenol,4,4'-(1,2-diethylethylene)di-, meso- (8CI); Cycloestrol; Erythrohexestrol;Estrifar; Estronal; Extra-Plex; Hexanoestrol; Hexestrofen; Hexestrol;Hexoestrol; Hexron; Hormoestrol; Mesohexestrol; NSC 9894; Sinestrol; Synestrol;Synoestrol; Synthovo; Syntrogene; meso-3,4-Bis(p-hydroxyphenyl)-n-hexane;meso-3,4-Di(p-hydroxyphenyl)-n-hexane; meso-Hexestrol

Identification
NamePhenol,4,4'-[(1R,2S)-1,2-diethyl-1,2-ethanediyl]bis-, rel-
CAS84-16-2
SynonymsPhenol,4,4'-(1,2-diethyl-1,2-ethanediyl)bis-, (R*,S*)-; Phenol,4,4'-(1,2-diethylethylene)di-, meso- (8CI); Cycloestrol; Erythrohexestrol;Estrifar; Estronal; Extra-Plex; Hexanoestrol; Hexestrofen; Hexestrol;Hexoestrol; Hexron; Hormoestrol; Mesohexestrol; NSC 9894; Sinestrol; Synestrol;Synoestrol; Synthovo; Syntrogene; meso-3,4-Bis(p-hydroxyphenyl)-n-hexane;meso-3,4-Di(p-hydroxyphenyl)-n-hexane; meso-Hexestrol
EINECS(EC#)201-518-1
Molecular FormulaC18H22 O2
Molecular Weight270.40
Chemical Properties
Appearancecrystalline solid
Safety Data

Hazard T: Toxic;
Risk 45
Safety

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Experimental teratogenic and reproductive effects. Mutation data reported. See also diethylstilbestrols.
Safety Information of Hexestrol (CAS NO.84-16-2):
Hazard Codes: TToxic
Risk Statements: 45  
45:  May cause cancer
Safety Statements: 53-45
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
53:  Avoid exposure - obtain special instruction before use 


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 743, 1982.
mouse LD50 oral 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 743, 1982.
mouse LD50 subcutaneous > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. 6, Pg. 744, 1982.
rat LD50 intraperitoneal 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 743, 1982.
rat LD50 oral > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. 744, 1982.
rat LD50 subcutaneous 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 743, 1982.

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