1,2,4-Triazine-3,5-diamine,6-(2,3-dichlorophenyl)- cas no:84057-84-1
Synonyms: 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine;6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;BW 430C;LTG;Lamictal;Lamictal XR;Lamidus;Lamotrigin;
Name1,2,4-Triazine-3,5-diamine,6-(2,3-dichlorophenyl)-
CAS84057-84-1
Synonyms3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine;6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;BW 430C;LTG;Lamictal;Lamictal XR;Lamidus;Lamotrigin;
EINECS(EC#)281-901-8
Molecular FormulaC9H7Cl2N5
Molecular Weight256.09
Appearancewhite crystallization
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard T: Toxic;
Risk R25
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XY5850700
- CHEMICAL NAME :
- 1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-
- CAS REGISTRY NUMBER :
- 84057-84-1
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C9-H7-Cl2-N5
- MOLECULAR WEIGHT :
- 256.11
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 19 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Cardiac - EKG changes not diagnostic of specified effects
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 342,1552,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 2 mg/kg/30H-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
- REFERENCE :
- PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,
Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 98,294,1996
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 205 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New
York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959-
Volume(issue)/page/year: 25,655,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 245 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New
York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959-
Volume(issue)/page/year: 25,655,1984
