84625-61-6|ItraconazoleProducts Supply - Chemical intermediates Network

Itraconazole cas no:84625-61-6

Synonyms: ITCZ;ITR;3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-pipera-zinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl);ITZ;Itraconazolum [Latin];R 51211;Itrizole;Itraconazole [USAN:BAN:INN:JAN];Itraconazole (JAN/USAN);Itrizole (TN);Itraconazol [Spanish];3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-;Sporanox (TN);Oriconazole;Sporanox;

Identification

NameItraconazole
CAS84625-61-6
SynonymsITCZ;ITR;3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-pipera-zinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl);ITZ;Itraconazolum [Latin];R 51211;Itrizole;Itraconazole [USAN:BAN:INN:JAN];Itraconazole (JAN/USAN);Itrizole (TN);Itraconazol [Spanish];3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-;Sporanox (TN);Oriconazole;Sporanox;
Molecular FormulaC₃₅H₃₈Cl₂N₈O₄
Molecular Weight705.63342

Chemical Properties

Appearanceoff-White crystalline solid
storage temp2-8°C

Safety Data

Hazard Xi:Irritant
Risk R36/37/38
Safety

Hazard Codes:? Irritant Xi, Harmful Xn
Risk Statements: 36/37/38-36/38-22?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R36/38: Irritating to eyes and skin.?
R22: Harmful if swallowed.
Safety Statements: 22-26-36?
S22: Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS Itraconazole (CAS NO.84625-61-6): XZ5481000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 200mg/kg (200mg/kg)	?	Reviews of Infectious Diseases. Vol. 9(Suppl,
guinea pig	LD50	oral	> 160mg/kg (160mg/kg)	?	Reviews of Infectious Diseases. Vol. 9(Suppl,
man	TDLo	oral	240mg/kg/6W-I (240mg/kg)	LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" LIVER: LIVER FUNCTION TESTS IMPAIRED	Lancet. Vol. 340, Pg. 251, 1992.
mouse	LD50	intravenous	46400ug/kg (46.4mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 25, Pg. 381, 1991.
mouse	LD50	oral	> 320mg/kg (320mg/kg)	?	Reviews of Infectious Diseases. Vol. 9(Suppl,
rat	LD50	intravenous	40mg/kg (40mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 25, Pg. 381, 1991.
rat	LD50	oral	> 320mg/kg (320mg/kg)	?	Reviews of Infectious Diseases. Vol. 9(Suppl,
women	TDLo	oral	32mg/kg/8D-I (32mg/kg)	SKIN AND APPENDAGES (SKIN): HAIR: OTHER	British Medical Journal. Vol. 293, Pg. 822, 1986.
women	TDLo	oral	140mg/kg/5W-I (140mg/kg)	LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" LIVER: LIVER FUNCTION TESTS IMPAIRED SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Lancet. Vol. 340, Pg. 251, 1992.

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Itraconazole cas no:84625-61-6

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