Itraconazole cas no:84625-61-6
Synonyms: ITCZ;ITR;3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-pipera-zinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl);ITZ;Itraconazolum [Latin];R 51211;Itrizole;Itraconazole [USAN:BAN:INN:JAN];Itraconazole (JAN/USAN);Itrizole (TN);Itraconazol [Spanish];3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-;Sporanox (TN);Oriconazole;Sporanox;
NameItraconazole
CAS84625-61-6
SynonymsITCZ;ITR;3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-pipera-zinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl);ITZ;Itraconazolum [Latin];R 51211;Itrizole;Itraconazole [USAN:BAN:INN:JAN];Itraconazole (JAN/USAN);Itrizole (TN);Itraconazol [Spanish];3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-;Sporanox (TN);Oriconazole;Sporanox;
Molecular FormulaC35H38Cl2N8O4
Molecular Weight705.63342
Appearanceoff-White crystalline solid
storage temp2-8°C
Hazard Xi:Irritant
Risk R36/37/38
Safety
Hazard Codes:?
Xi,
Xn
Risk Statements: 36/37/38-36/38-22?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R36/38: Irritating to eyes and skin.?
R22: Harmful if swallowed.
Safety Statements: 22-26-36?
S22: Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS Itraconazole (CAS NO.84625-61-6): XZ5481000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
oral |
> 200mg/kg (200mg/kg) |
? |
Reviews of Infectious Diseases. Vol. 9(Suppl, |
| guinea pig |
LD50 |
oral |
> 160mg/kg (160mg/kg) |
? |
Reviews of Infectious Diseases. Vol. 9(Suppl, |
| man |
TDLo |
oral |
240mg/kg/6W-I (240mg/kg) |
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
LIVER: LIVER FUNCTION TESTS IMPAIRED |
Lancet. Vol. 340, Pg. 251, 1992. |
| mouse |
LD50 |
intravenous |
46400ug/kg (46.4mg/kg) |
? |
Kiso to Rinsho. Clinical Report. Vol. 25, Pg. 381, 1991. |
| mouse |
LD50 |
oral |
> 320mg/kg (320mg/kg) |
? |
Reviews of Infectious Diseases. Vol. 9(Suppl, |
| rat |
LD50 |
intravenous |
40mg/kg (40mg/kg) |
? |
Kiso to Rinsho. Clinical Report. Vol. 25, Pg. 381, 1991. |
| rat |
LD50 |
oral |
> 320mg/kg (320mg/kg) |
? |
Reviews of Infectious Diseases. Vol. 9(Suppl, |
| women |
TDLo |
oral |
32mg/kg/8D-I (32mg/kg) |
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
British Medical Journal. Vol. 293, Pg. 822, 1986. |
| women |
TDLo |
oral |
140mg/kg/5W-I (140mg/kg) |
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
LIVER: LIVER FUNCTION TESTS IMPAIRED
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Lancet. Vol. 340, Pg. 251, 1992. |
