19-Norpregna-4,9,11-trien-20-yn-3-one,17-hydroxy-, (17a)- cas no:848-21-5

Name19-Norpregna-4,9,11-trien-20-yn-3-one,17-hydroxy-, (17a)-
CAS848-21-5
Synonyms19-Nor-17a-pregna-4,9,11-trien-20-yn-3-one,17-hydroxy- (7CI,8CI); 17-Hydroxy-19-nor-17a-pregna-4,9,11-trien-20-yn-3-one; 17a-Ethynyl-17-hydroxyestratrien-3-one;17a-Ethynyl-17b-hydroxy-3-oxo-4,9,11-estratriene;17a-Ethynyl-3-oxo-4,9,11-estratrien-17b-ol; 17a-Ethynyl-4,9,11-estratrien-17b-ol-3-one; 3-Oxo-17a-ethynyl-17b-hydroxyestra-4,9,11-triene; A301; A 301 (steroid); NSC 101105; Norgestrienone; Ogyline; Planor; R 2010; RU2010
EINECS(EC#)212-698-6
Molecular FormulaC20H22 O2
Molecular Weight294.42

refractive index1.615

Safety

Human female reproductive effects by implant and intravaginal routes: changes in menstrual cycle and fertility. When heated to decomposition it emits acrid smoke and irritating fumes.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

RC8960080

CHEMICAL NAME :

19-Nor-17-alpha-pregna-4,9,11-trien-20-yn-3-one, 17-hydroxy-

CAS REGISTRY NUMBER :

848-21-5

LAST UPDATED :

199706

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C20-H22-O2

MOLECULAR WEIGHT :

294.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Implant

DOSE :

1168 ug/kg

SEX/DURATION :

female 52 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 18,411,1978

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Implant

DOSE :

1642 ug/kg

SEX/DURATION :

female 52 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 18,429,1978

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravaginal

DOSE :

1 mg/kg

SEX/DURATION :

female 36 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 20,511,1979