1H-1,4-Diazepine,1-[(4-chlorophenyl)phenylmethyl]hexahydro-4-methyl- cas no:848-53-3

Name1H-1,4-Diazepine,1-[(4-chlorophenyl)phenylmethyl]hexahydro-4-methyl-
CAS848-53-3
Synonyms1H-1,4-Diazepine,1-(p-chloro-a-phenylbenzyl)hexahydro-4-methyl-(7CI,8CI); (?à)-Homochlorcyclizine;1-(4-Chlorodiphenylmethyl)-4-methyl-2,3,4,5,6,7-hexahydro-1,4-diazepine;1-(p-Chloro-a-phenylbenzyl)-4-methylhomopiperazine;1-(p-Chloro-a-phenylbenzyl)hexahydro-4-methyl-1H-1,4-diazepine;Curosajin; Homochlorcyclizine; Homochlorocyclizine; Homoclomine; Homodamon;Homorestar; Lysilan; N-(p-Chlorobenzhydryl)-N'-methylhomopiperazine; NSC 25132;SA 97; Sankumin; Wicron
EINECS(EC#)212-699-1
Molecular FormulaC19H23 Cl N2
Molecular Weight314.89

refractive index1.58

Safety

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition Homochlorcyclizine (CAS NO.848-53-3) emits toxic vapors of NO_x and Cl⁻.

1.		orl-rat LD50:490 mg/kg		YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 22 (1980),375.
2.		ipr-rat LD50:81 mg/kg		YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 22 (1980),375.
3.		ivn-rat LD50:36 mg/kg		YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 22 (1980),375.
4.		orl-mus LD50:343 mg/kg		YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 22 (1980),375.
5.		ipr-mus LD50:98 mg/kg		YKKZAJ    Yakugaku Zasshi. Journal of Pharmacy. 92 (1972),1339.
6.		scu-mus LD50:164 mg/kg		YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 22 (1980),375.
7.		ivn-mus LD50:47,800 µg/kg		YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 22 (1980),375.
8.		orl-dog LD50:>200 mg/kg		OYYAA2    Oyo Yakuri. Pharmacometrics. 1 (1967),168.
9.		ipr-dog LD50:50 mg/kg		OYYAA2    Oyo Yakuri. Pharmacometrics. 1 (1967),168.
10.		ivn-dog LD50:20 mg/kg		OYYAA2    Oyo Yakuri. Pharmacometrics. 1 (1967),168.
11.