man |
LDLo |
oral |
5714ug/kg/2D- (5.714mg/kg) |
BEHAVIORAL: COMA
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
LIVER: LIVER FUNCTION TESTS IMPAIRED |
Lancet. Vol. 343, Pg. 738, 1994. |
man |
TDLo |
oral |
21mg/kg/3D-I (21mg/kg) |
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
KIDNEY, URETER, AND BLADDER: PROTEINURIS
KIDNEY, URETER, AND BLADDER: HEMATURIA |
Annals of Pharmacotherpy. Vol. 29, Pg. 84, 1995. |
man |
TDLo |
oral |
21429ug/kg/3D (21.429mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: TOXIC PSYCHOSIS |
Annals of Pharmacotherpy. Vol. 26, Pg. 930, 1992. |
man |
TDLo |
oral |
129mg/kg/6D-I (129mg/kg) |
BEHAVIORAL: REGIDITY |
Journal of Clinical Psychiatry. Vol. 54, Pg. 115, 1993. |
man |
TDLo |
oral |
200mg/kg (200mg/kg) |
BEHAVIORAL: TREMOR
GASTROINTESTINAL: NAUSEA OR VOMITING
GASTROINTESTINAL: OTHER CHANGES |
Annals of Pharmacotherpy. Vol. 28, Pg. 805, 1994. |
mouse |
LD50 |
intraperitoneal |
1165mg/kg (1165mg/kg) |
? |
Ensho. Japanese Journal of Inflammation. Vol. 11, Pg. 343, 1991. |
mouse |
LD50 |
intravenous |
122mg/kg (122mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Korean Journal of Toxicology. Vol. 8, Pg. 161, 1993. |
mouse |
LD50 |
oral |
5gm/kg (5000mg/kg) |
? |
Journal of Medicinal Chemistry. Vol. 33, Pg. 1344, 1990. |
mouse |
LD50 |
subcutaneous |
> 1gm/kg (1000mg/kg) |
? |
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 297, 1992. |
rat |
LD50 |
intravenous |
207mg/kg (207mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Korean Journal of Toxicology. Vol. 8, Pg. 161, 1993. |
rat |
LD50 |
oral |
> 2gm/kg (2000mg/kg) |
? |
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 297, 1992. |
rat |
LD50 |
subcutaneous |
> 1gm/kg (1000mg/kg) |
? |
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 297, 1992. |
women |
TDLo |
multiple routes |
40mg/kg/6D-I (40mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Acta Clinica Belgica. Vol. 49, Pg. 173, 1994. |
women |
TDLo |
oral |
10mg/kg (10mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
GASTROINTESTINAL: NAUSEA OR VOMITING |
Allergy. Vol. 50(Suppl, |
women |
TDLo |
oral |
40mg/kg/2D-I (40mg/kg) |
BEHAVIORAL: HEADACHE
BLOOD: EOSINOPHILIA |
American Journal of Medicine. Vol. 87, Pg. 589, 1989. |
women |
TDLo |
oral |
135mg/kg/3D-I (135mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Archives of Internal Medicine. Vol. 153, Pg. 1258, 1993. |
women |
TDLo |
oral |
280mg/kg/2W-I (280mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" |
American Journal of Kidney Diseases. Vol. 22, Pg. 598, 1993. |