Phthalazine,1-hydrazinyl- cas no:86-54-4
Synonyms: 1(2H)-Phthalazinone,hydrazone (9CI); Phthalazine, 1-hydrazino- (6CI,8CI); 1-Hydrazinophthalazine;1-Phthalazinylhydrazine; Apresolin; Apresoline; Apressin; Apressin(pharmaceutical); Aprezolin; Ba 5968; C 5968; Ciba 5968; Hidralazin;Hipoftalin; Hydralazin; Hydralazine; Hypophthalin; NSC 126699
NamePhthalazine,1-hydrazinyl-
CAS86-54-4
Synonyms1(2H)-Phthalazinone,hydrazone (9CI); Phthalazine, 1-hydrazino- (6CI,8CI); 1-Hydrazinophthalazine;1-Phthalazinylhydrazine; Apresolin; Apresoline; Apressin; Apressin(pharmaceutical); Aprezolin; Ba 5968; C 5968; Ciba 5968; Hidralazin;Hipoftalin; Hydralazin; Hydralazine; Hypophthalin; NSC 126699
EINECS(EC#)201-680-3
Molecular FormulaC8H8 N4
Molecular Weight160.18
AppearanceYellow needles from methanol.
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Safety
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, cardiomyopathy, changes in coronary arteries. Human teratogenic effects by an unspecified route: developmental abnormalities of the blood and lymphatic system. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
| 1. |
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mma-sat 500 µg/plate
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MUREAV Mutation Research. 66 (1979),247. |
| 2. |
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slt-dmg-unr 200 mmol/L/6H
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MUREAV Mutation Research. 120 (1983),233. |
| 3. |
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orl-man TDLo:2086 mg/kg/2Y-I:SKN
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BMJOAE British Medical Journal. 289 (1984),410. |
| 4. |
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orl-wmn TDLo:730 mg/kg/2Y-I:SKN
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BMJOAE British Medical Journal. 289 (1984),410. |
| 5. |
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ims-man TDLo:89 µg/kg:CVS
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EJPEDT European Journal of Pediatrics. 145 (1986),318. |
| 6. |
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orl-rat LD50:90 mg/kg
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PLRCAT Pharmacological Research Communications. 8 (1976),295. |
| 7. |
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ipr-rat LD50:25 mg/kg
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JPETAB Journal of Pharmacology and Experimental Therapeutics. 143 (1964),7. |
| 8. |
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ivn-rat LD50:34 mg/kg
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JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 40 (1951),559. |
| 9. |
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orl-mus LD50:122 mg/kg
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PLRCAT Pharmacological Research Communications. 8 (1976),295. |
| 10. |
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ipr-mus LD50:100 mg/kg
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JMCMAR Journal of Medicinal Chemistry. 22 (1979),671. |
| 11. |
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