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Dasatinib monohydrate cas no:863127-77-9

Synonyms: N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate

Identification
NameDasatinib monohydrate
CAS863127-77-9
SynonymsN-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate
Molecular FormulaC22H26ClN7O2S?H2O
Molecular Weight506.02
Toxicity

?Neutropenia and myelosuppression were common toxic effects. Fifteen patients in the above-mentioned study developed pleural effusions, which were felt to be a side effect of dasatinib. Some of these patients required thoracentesis or pleurodesis to treat the effusions. Other adverse events included mild to moderate diarrhea, peripheral edema, and headache. A small number of patients developed abnormal liver function tests which returned to normal without dose adjustments. Mild hypocalcemia was also noted, but did not appear to cause any significant problems.

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Datang (Hangzhou) Pharmachem Co., Ltd.
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Nanjing Ange Pharmaceutical Co., Ltd.
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Zhejiang Golden Pharma Co., Limited
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Yingxuan Chempharm Co., Ltd.
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China ShengDa Pharmaceutical Company
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Changzhou Kessie Chemical Co., Ltd.
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Zhejiang Esun Chemical Co., Ltd.
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Tecoland Corporation
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Trust & We Co., Ltd.
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Beijing Ribio Biotech Co., Ltd.
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Facus Pharmaceutical Co., Ltd.
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Taizhou Huading Chemical Industry Co., Ltd.
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Beijing Bcory Pharm-chemicals Tech.Co., Ltd.
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Parling Trading Company
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Zhejiang Wonderful Pharma & Chem Co.
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