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Dasatinib monohydrate cas no:863127-77-9

Synonyms: N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate

Identification
NameDasatinib monohydrate
CAS863127-77-9
SynonymsN-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate
Molecular FormulaC22H26ClN7O2S?H2O
Molecular Weight506.02
Toxicity

?Neutropenia and myelosuppression were common toxic effects. Fifteen patients in the above-mentioned study developed pleural effusions, which were felt to be a side effect of dasatinib. Some of these patients required thoracentesis or pleurodesis to treat the effusions. Other adverse events included mild to moderate diarrhea, peripheral edema, and headache. A small number of patients developed abnormal liver function tests which returned to normal without dose adjustments. Mild hypocalcemia was also noted, but did not appear to cause any significant problems.

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Shanghai Longschem Co.,Ltd
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Datang (Hangzhou) Pharmachem Co., Ltd.
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Nanjing Ange Pharmaceutical Co., Ltd.
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Yongyi Biotechnology Co,.Ltd
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Melone Pharmaceutical Co., Ltd.
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Taizhou Taifeng Chemical Co., Ltd.
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Address: Jiaojiang District, Taizhou City, Zhejiang Province, China
Zhejiang Golden Pharma Co., Limited
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Changzhou Carbochem Co.,Ltd
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SPE Chemicals Co., Ltd.
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Address: 1615 Room, TongHua building, NO.345, Jinxiang Road, Pudong, Shanghai 201206,
China ShengDa Pharmaceutical Company
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Address: Shenzhen Tech-Innovatio,The Tenth Road,South, Shenzhen, GuangDong 518058,
Changzhou Kessie Chemical Co., Ltd.
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Address: No-13, Guanghua West Road, Changzhou, Jiangsu,
Beijing Chemsynlab Pharmaceutical Science & Technology Co. Ltd
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Address: No. 18, Jinyuan Road, Daxing Industrial Developing District, Beijing 10262,
Yore Chemipharm Co., Limited
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Address: Lane 45, North, Wangtong Road, Ningbo, Zhejiang,
BrightGene Bio-Medical Technology Co., Ltd.
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Address: No.1326, Binhe Road, Suzhou New district, Suzhou, Jiangsu 215011,
Zhejiang Esun Chemical Co., Ltd.
Tel:86-571-56286531
Address: Sandun, Xihu Industry Park, Hangzhou City, Zhejiang 310030,

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