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Dasatinib monohydrate cas no:863127-77-9

Synonyms: N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate

Identification
NameDasatinib monohydrate
CAS863127-77-9
SynonymsN-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate
Molecular FormulaC22H26ClN7O2S?H2O
Molecular Weight506.02
Toxicity

?Neutropenia and myelosuppression were common toxic effects. Fifteen patients in the above-mentioned study developed pleural effusions, which were felt to be a side effect of dasatinib. Some of these patients required thoracentesis or pleurodesis to treat the effusions. Other adverse events included mild to moderate diarrhea, peripheral edema, and headache. A small number of patients developed abnormal liver function tests which returned to normal without dose adjustments. Mild hypocalcemia was also noted, but did not appear to cause any significant problems.

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Nanjing Ange Pharmaceutical Co., Ltd.
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Address: Room 2309-2311, Technical garden B place, Industrial university, NO.5 Xinmofang Road, Nanjing, China
Yongyi Biotechnology Co,.Ltd
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Melone Pharmaceutical Co., Ltd.
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Zhejiang Golden Pharma Co., Limited
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Changzhou Carbochem Co.,Ltd
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Yingxuan Chempharm Co., Ltd.
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China ShengDa Pharmaceutical Company
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Address: Shenzhen Tech-Innovatio,The Tenth Road,South, Shenzhen, GuangDong 518058,
Changzhou Kessie Chemical Co., Ltd.
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Beijing Chemsynlab Pharmaceutical Science & Technology Co. Ltd
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BrightGene Bio-Medical Technology Co., Ltd.
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Zhejiang Esun Chemical Co., Ltd.
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Tecoland Corporation
Tel:+1-(732)-603-9577
Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428,
AOKChem Co., Ltd.
Tel:+86-(21)-50791030 / 68712331
Address: Room 203, Block D, No.333 Cailun Road, Zhangjiang High-tech Park, Shanghai 201203,
Beijing Ribio Biotech Co., Ltd.
Tel:+86-(10)-58957280
Address: Room 710, XinCaiLiao ChuangYe Building, No.7 FengHuiZhong Road. HaiDian District, Beijing 100094,
Facus Pharmaceutical Co., Ltd.
Tel:+86-(574)-6237-8411
Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800,

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