86386-73-4|FluconazoleProducts Supply - Chemical intermediates Network

Fluconazole cas no:86386-73-4

Synonyms: Flucostat;Fluconazolum [Latin];Biozolene;FLU;Zemyc;Forcan;FCZ;Diflucan;Flusol;Flukezol;Pritenzol;2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol;Biocanol;Fluzone;Cryptal;UK 49858;Syscan;Alflucoz;1H-1,2,4-Triazole-1-ethanol,R-(2,4-difluorophenyl)- R-(1H-1,2,4-triazol-1-ylmethyl)-;FLZ;Diflucan (TN);Flucazol;FLC;Canzol;Oxifugol;Fluconazole (JAN/USAN);Fungata;Mutum;FLCZ;Baten;alpha-(2,4-Difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol;Fluconazol [Spanish];Triflucan;Afungil;Zonal;Elazor;

Identification

NameFluconazole
CAS86386-73-4
SynonymsFlucostat;Fluconazolum [Latin];Biozolene;FLU;Zemyc;Forcan;FCZ;Diflucan;Flusol;Flukezol;Pritenzol;2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol;Biocanol;Fluzone;Cryptal;UK 49858;Syscan;Alflucoz;1H-1,2,4-Triazole-1-ethanol,R-(2,4-difluorophenyl)- R-(1H-1,2,4-triazol-1-ylmethyl)-;FLZ;Diflucan (TN);Flucazol;FLC;Canzol;Oxifugol;Fluconazole (JAN/USAN);Fungata;Mutum;FLCZ;Baten;alpha-(2,4-Difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol;Fluconazol [Spanish];Triflucan;Afungil;Zonal;Elazor;
Molecular FormulaC₁₃H₁₂F₂N₆O
Molecular Weight306.270786

Chemical Properties

Appearancewhite or off white crystalline powder
storage temp?20°C

Safety Data

Hazard Xn: Harmful;
Risk R36/37/38
Safety

Hazard Codes:? Harmful Xn,Xi
Risk Statements:?36/37/38-20/21/22
R36/37/38: Irritating to eyes, respiratory system and skin.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements:?26-36/37/39-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S24/25: Avoid contact with skin and eyes.
RTECS:?XZ4810000
?Fluconazole (CAS NO.86386-73-4) is contraindicated in patients with:
Pregnancy
Known hypersensitivity to fluconazole or other azole antifungals
Concomitant use of cisapride, due to risk of serious cardiac arrhythmias (relative contraindication).

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	> 100mg/kg (100mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
dog	LD50	oral	> 300mg/kg (300mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
man	TDLo	oral	60mg/kg/3W-I (60mg/kg)	?	Postgraduate Medical Journal. Vol. 67, Pg. 1084, 1991.
man	TDLo	oral	60mg/kg/3W-I (60mg/kg)	?	Postgraduate Medical Journal. Vol. 67, Pg. 1084, 1991.
man	TDLo	oral	1040mg/kg/26W (1040mg/kg)	SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Annals of Internal Medicine. Vol. 123, Pg. 354, 1995.
mouse	LD50	intraperitoneal	1273mg/kg (1273mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
mouse	LD50	intravenous	> 200mg/kg (200mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
mouse	LD50	oral	1408mg/kg (1408mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
mouse	LD50	unreported	> 1gm/kg (1000mg/kg)	?	Antimicrobial Agents and Chemotherapy. Vol. 29, Pg. 161, 1986.
rat	LD50	intraperitoneal	> 941mg/kg (941mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
rat	LD50	intravenous	> 200mg/kg (200mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
rat	LD50	oral	1271mg/kg (1271mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
rat	LD50	unreported	> 1gm/kg (1000mg/kg)	?	Antimicrobial Agents and Chemotherapy. Vol. 29, Pg. 161, 1986.
women	TDLo	multiple routes	426mg/kg/37D- (426mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Annals of Internal Medicine. Vol. 131, Pg. 797, 1999.
women	TDLo	oral	1456mg/kg/26W (1456mg/kg)	SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Annals of Internal Medicine. Vol. 123, Pg. 354, 1995.

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ELSaad Pharmaceutical Industries.: Tel:; Address:

Sinochem Jiangsu Imp. & Exp. Corp.: Tel:+86-(512)-68621909,68622022; Address: 12/F,Internatiional Trade Tower,6 Xihuan Road Suzhou, iangsu 215004,

Heer Pharma Pvt. Ltd.: Tel:+91-(22)-24327226; Address: Unit 317,Unique Ind Est,TwinTowerLane, Off Veer SavarkarMarg, Prabhadevi, Mumbai, Maharashtra 400 025,

Shenzhen Asiatop Carnitine Technology Co., Ltd.: Tel:+86-(755)-27633391; Address: Huangfengling Industrial Zone, Shiyan Town, Baoan District, Shenzhen 518108,

Shanghai Richem International Co., Ltd.: Tel:+86-(21)-31263688; Address: Room 603, Golden Eagle Mansion A, No.1518 Minsheng Road, Pudong, Shanghai 200135,

Beijing Nordhuns Chemical Technology Co., Ltd.: Tel:+86-(10)-84929330, 86972915; Address: 202 Xinhengji Office Building, No.66 Beiyuan Road, Chaoyang, beijing,

Shakti Bioscience Ltd.: Tel:91-22-64523685; Address: 101, Tulsi Tower, 51 TPS Road, Borivali (West), Mumbai, Maharashtra 400092,

Lifeline Industries Limited: Tel:+91-(22)-2871 0505; Address: 3rd Floor, Mastermind III, Aarey Milk Colony, Goregaon East, Mumbai, Maharashtra 400065,

Vishal Pharmakem: Tel:+91-(22)-65113626, 32680978; Address: 1204, Mayuresh Cosmos, Plot No. 37, Sector 11, CBD Belapur, Mumbai, Maharashtra 400614,

S.V. Enterprises: Tel:+91-(22)-23455973; Address: 205, Khajurwala Chambers, 313/315, Narshi Natha Street, Mumbai, Maharashtra 400009,

Sibram Pharmaceuticals: Tel:+91-(22)-67997876; Address: E-305, 3rd Floor Kailas Industrial Complex, Park Site, Vikhroli (West), Mumbai, Maharashtra 400079,

Laboratorios Lesvi: Tel:34 93 475 96 00; Address: Avda. Barcelona, 69,08970 Sant Joan Desp?, Barcelona Espa?a,

Nanjing Hicin Pharmaceutical Co., Ltd.: Tel:+86-(25)-83241000; Address: 70# Matai Street, Nanjing, Jiangsu 210009,

Emerald-Shanghai Incorporation: Tel:+86-(21)-6864-0170; Address: Dong Fang Road 2851 Lane 22-1202, Shanghai,

Ningbo Fengrui Fine Chemical Ltd.: Tel:+86-574-87720208; Address: Caihong North Road

Fluconazole cas no:86386-73-4

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