86386-73-4|FluconazoleProducts Supply - Chemical intermediates Network

Fluconazole cas no:86386-73-4

Synonyms: Flucostat;Fluconazolum [Latin];Biozolene;FLU;Zemyc;Forcan;FCZ;Diflucan;Flusol;Flukezol;Pritenzol;2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol;Biocanol;Fluzone;Cryptal;UK 49858;Syscan;Alflucoz;1H-1,2,4-Triazole-1-ethanol,R-(2,4-difluorophenyl)- R-(1H-1,2,4-triazol-1-ylmethyl)-;FLZ;Diflucan (TN);Flucazol;FLC;Canzol;Oxifugol;Fluconazole (JAN/USAN);Fungata;Mutum;FLCZ;Baten;alpha-(2,4-Difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol;Fluconazol [Spanish];Triflucan;Afungil;Zonal;Elazor;

Identification

NameFluconazole
CAS86386-73-4
SynonymsFlucostat;Fluconazolum [Latin];Biozolene;FLU;Zemyc;Forcan;FCZ;Diflucan;Flusol;Flukezol;Pritenzol;2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol;Biocanol;Fluzone;Cryptal;UK 49858;Syscan;Alflucoz;1H-1,2,4-Triazole-1-ethanol,R-(2,4-difluorophenyl)- R-(1H-1,2,4-triazol-1-ylmethyl)-;FLZ;Diflucan (TN);Flucazol;FLC;Canzol;Oxifugol;Fluconazole (JAN/USAN);Fungata;Mutum;FLCZ;Baten;alpha-(2,4-Difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol;Fluconazol [Spanish];Triflucan;Afungil;Zonal;Elazor;
Molecular FormulaC₁₃H₁₂F₂N₆O
Molecular Weight306.270786

Chemical Properties

Appearancewhite or off white crystalline powder
storage temp?20°C

Safety Data

Hazard Xn: Harmful;
Risk R36/37/38
Safety

Hazard Codes:? Harmful Xn,Xi
Risk Statements:?36/37/38-20/21/22
R36/37/38: Irritating to eyes, respiratory system and skin.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements:?26-36/37/39-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S24/25: Avoid contact with skin and eyes.
RTECS:?XZ4810000
?Fluconazole (CAS NO.86386-73-4) is contraindicated in patients with:
Pregnancy
Known hypersensitivity to fluconazole or other azole antifungals
Concomitant use of cisapride, due to risk of serious cardiac arrhythmias (relative contraindication).

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	> 100mg/kg (100mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
dog	LD50	oral	> 300mg/kg (300mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
man	TDLo	oral	60mg/kg/3W-I (60mg/kg)	?	Postgraduate Medical Journal. Vol. 67, Pg. 1084, 1991.
man	TDLo	oral	60mg/kg/3W-I (60mg/kg)	?	Postgraduate Medical Journal. Vol. 67, Pg. 1084, 1991.
man	TDLo	oral	1040mg/kg/26W (1040mg/kg)	SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Annals of Internal Medicine. Vol. 123, Pg. 354, 1995.
mouse	LD50	intraperitoneal	1273mg/kg (1273mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
mouse	LD50	intravenous	> 200mg/kg (200mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
mouse	LD50	oral	1408mg/kg (1408mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
mouse	LD50	unreported	> 1gm/kg (1000mg/kg)	?	Antimicrobial Agents and Chemotherapy. Vol. 29, Pg. 161, 1986.
rat	LD50	intraperitoneal	> 941mg/kg (941mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
rat	LD50	intravenous	> 200mg/kg (200mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
rat	LD50	oral	1271mg/kg (1271mg/kg)	?	Drugs in Japan Vol. -, Pg. 983, 1990.
rat	LD50	unreported	> 1gm/kg (1000mg/kg)	?	Antimicrobial Agents and Chemotherapy. Vol. 29, Pg. 161, 1986.
women	TDLo	multiple routes	426mg/kg/37D- (426mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Annals of Internal Medicine. Vol. 131, Pg. 797, 1999.
women	TDLo	oral	1456mg/kg/26W (1456mg/kg)	SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Annals of Internal Medicine. Vol. 123, Pg. 354, 1995.

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Fluconazole cas no:86386-73-4

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