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vinblastine cas no:865-21-4

Synonyms: Vincaleukoblastine;

Identification
Namevinblastine
CAS865-21-4
SynonymsVincaleukoblastine;
EINECS(EC#)212-734-0
Molecular FormulaC46H58N4O9
Molecular Weight810.9856
Chemical Properties
AppearancePOWDER
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Safety

Human poison by intravenous route. Experimental poison by intraperitoneal route. Human systemic effects by intravenous and ocular routes: visual field changes, conjunctiva irritation and other eye effects, cardiomyopathy including infarction, and changes in bone marrow. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Used as an antineoplastic agent. See also VINCALEUKOBLASTINE SULFATE (1:1) (SALT).
RIDADR: 1544
HazardClass: 6.1(a)
PackingGroup: II


Toxicity
1.    

dni-hmn:oth 200 µg/L

    26QZAP    Advances in Antimicrobial and Antineoplastic Chemotherapy, Progress in Research and Clinical Application. 2 (1972),377.
2.    

cyt-mus-ipr 900 µg/kg

    ENMUDM    Environmental Mutagenesis. 8 (1986),273.
3.    

ivn-man LDLo:2319 µg/kg/38W-I:CVS

    LANCAO    Lancet. 2 (1980),692.
4.    

ocu-hmn TDLo:14 µg/kg:EYE

    BJOPAL    British Journal of Ophthalmology. 62 (1978),97.
5.    

unr-man TDLo:80 µg/kg:BLD

    CCROBU    Cancer Chemotherapy Reports, Part 1. 50 (1966),219.
6.    

ipr-rat LD50:1 mg/kg

    VINIT*    Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) #3713-83 .

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