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CRF (human and rat) cas no:86784-80-7

Synonyms: Corticotropin-releasingfactor (sheep), 2-L-glutamic acid-22-L-alanine-23-L-arginine-25-L-glutamicacid-38-L-methionine-39-L-glutamic acid-41-L-isoleucinamide-;Corticobiss;Corticotropin-releasing factor (Mesocricetusauratus);Corticotropin-releasingfactor (human);Human ACTH-releasing factor;Human CRF(1-41);Humancorticorelin;Human corticotropin-releasing factor;Human corticotropin-releasing hormone-41;Human/rat CRF;L-Isoleucinamide, L-seryl-L-a-glutamyl-L-a-glutamyl-L-prolyl-L-prolyl-L-isoleucyl-L-seryl-L-leucyl-L-a-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-a-glutamyl-L-valyl-L-leucyl-L-a-glutamyl-L-methionyl-L-alanyl-L-arginyl-L-alanyl-L-a-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-L-leucyl-L-methionyl-L-a-glutamyl-L-isoleucyl-;MCI 028;Rat ACTH-releasing hormone;Rat CRF;Rat CRF(1-41);Rat CRF-41;Ratcorticotropin-releasing factor;Rat corticotropin-releasing factor-41;Rathypothalamic CRF;Rat/human CRF;Rat/human corticotropin-releasing factor;Xerecept;rCRF-41;Corticotropin Releasing Factor, human, rat;

Identification
NameCRF (human and rat)
CAS86784-80-7
SynonymsCorticotropin-releasingfactor (sheep), 2-L-glutamic acid-22-L-alanine-23-L-arginine-25-L-glutamicacid-38-L-methionine-39-L-glutamic acid-41-L-isoleucinamide-;Corticobiss;Corticotropin-releasing factor (Mesocricetusauratus);Corticotropin-releasingfactor (human);Human ACTH-releasing factor;Human CRF(1-41);Humancorticorelin;Human corticotropin-releasing factor;Human corticotropin-releasing hormone-41;Human/rat CRF;L-Isoleucinamide, L-seryl-L-a-glutamyl-L-a-glutamyl-L-prolyl-L-prolyl-L-isoleucyl-L-seryl-L-leucyl-L-a-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-a-glutamyl-L-valyl-L-leucyl-L-a-glutamyl-L-methionyl-L-alanyl-L-arginyl-L-alanyl-L-a-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-L-leucyl-L-methionyl-L-a-glutamyl-L-isoleucyl-;MCI 028;Rat ACTH-releasing hormone;Rat CRF;Rat CRF(1-41);Rat CRF-41;Ratcorticotropin-releasing factor;Rat corticotropin-releasing factor-41;Rathypothalamic CRF;Rat/human CRF;Rat/human corticotropin-releasing factor;Xerecept;rCRF-41;Corticotropin Releasing Factor, human, rat;
Molecular FormulaC208H344N60O63S2
Molecular Weight4758.24
Chemical Properties
storage temp−20°C
Safety Data

Safety

Moderately toxic by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and SOx.


Toxicity
1.    

ivn-rat LD50:>1 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 20 (Suppl 5),(1992),S1241.
2.    

ivn-dog LD50:>1 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 20 (Suppl 5),(1992),S1241.

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