4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-, (2S,5R,6R)- cas no:87-08-1

Name4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-, (2S,5R,6R)-
CAS87-08-1
Synonyms4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)- (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-,[2S-(2a,5a,6b)]-;6-(Phenoxyacetamido)penicillanic acid; Acipen-V; Calcipen; Crystapen V;Distaquaine V; Eskacillin V; Fenacilin; Meropenin; Oracillin; Oracilline;Oratren; Orocillin; Ospen; Pen-Oral; Pen-Vee; Pen-vee-oral; Penicillin V;Penicillin, phenoxymethyl-; Phenocillin; Phenopenicillin; Phenospen;Phenoxymethylpenicillin; Phenoxymethylpenicillinic acid; Stabicillin; V-Cil;V-Cillin; V-Cylina; V-Cyline; V-Tablopen; Vebecillin
EINECS(EC#)201-722-0
Molecular FormulaC16H18 N2 O5 S
Molecular Weight350.38952

Appearancewhite to off-white crystalline powder
storage temp−20°C

Hazard Not regulated UN NO.
Risk R42/43
Safety

Poison by intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: impaired liver function, dermatitis, fever. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO_x and NO_x.
Hazard Codes of Penicillin V (CAS NO.87-08-1): Xn
Risk Statements: 42/43 
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 22-36 
S22: Do not breathe dust. 
S36: Wear suitable protective clothing.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intramuscular	1096mg/kg (1096mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
guinea pig	LD50	intraperitoneal	822mg/kg (822mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse	LD50	intramuscular	> 1775mg/kg (1775mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse	LD50	intraperitoneal	1351mg/kg (1351mg/kg)		Antibiotics Annual. Vol. 3, Pg. 540, 1955/1956.
mouse	LD50	oral	6578mg/kg (6578mg/kg)		Antibiotiki. Vol. 3(4), Pg. 37, 1958.
mouse	LD50	subcutaneous	> 4gm/kg (4000mg/kg)		Antibiotics Annual. Vol. 3, Pg. 540, 1955/1956.
rat	LD50	intramuscular	> 1600mg/kg (1600mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat	LD50	intraperitoneal	> 2gm/kg (2000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat	LD50	intravenous	> 1775mg/kg (1775mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat	LD50	oral	> 2220mg/kg (2220mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
women	TDLo	oral	10mg/kg/2D (10mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Lancet. Vol. 2, Pg. 1297, 1976.