87-33-2|isosorbide dinitrateProducts Supply - Chemical intermediates Network

isosorbide dinitrate cas no:87-33-2

Synonyms: 1,4:3,6-dianhydrosorbitol 2,5-dinitrate; sorbide nitrate; Isosobide dinitrate

Identification

Nameisosorbide dinitrate
CAS87-33-2
Synonyms1,4:3,6-dianhydrosorbitol 2,5-dinitrate; sorbide nitrate; Isosobide dinitrate
EINECS(EC#)201-740-9
Molecular FormulaC6H8N2O8
Molecular Weight236.14

Chemical Properties

Appearancewhite crystalline powder
refractive index1.537
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass1.1A

Safety Data

Hazard Xn:Harmful;
Risk R5;R22
Safety

Moderately toxic by ingestion, intraperitoneal, intramuscular, and subcutaneous routes. Experimental reproductive effects. Mutation data reported. A flammable solid. When heated to decomposition it emits toxic fumes of NO_x. A coronary vasodilator.
Hazard Codes: Harmful Xn
Risk Statements: 5-22
R5 :Heating may cause an explosion.
R22:Harmful if swallowed.
Safety Statements: 36
S36:Wear suitable protective clothing.
RIDADR: UN 2907
HazardClass: 1.1A
PackingGroup: II

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	unreported	1109mg/kg (1109mg/kg)		French Demande Patent Document. Vol. #2454807,
man	TDLo	oral	1714ug/kg/3D- (1.714mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Australian and New Zealand Journal of Medicine. Vol. 27, Pg. 596, 1997.
mouse	LD50	intramuscular	1080mg/kg (1080mg/kg)		Drugs in Japan Vol. 6, Pg. 72, 1982.
mouse	LD50	intraperitoneal	720mg/kg (720mg/kg)		Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973.
mouse	LD50	intravenous	> 40mg/kg (40mg/kg)	BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
mouse	LD50	oral	1050mg/kg (1050mg/kg)		Drugs in Japan Vol. 6, Pg. 72, 1982.
mouse	LD50	subcutaneous	1050mg/kg (1050mg/kg)		Drugs in Japan Vol. 6, Pg. 72, 1982.
rabbit	LD50	intravenous	> 40mg/kg (40mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
rat	LD50	intramuscular	> 2gm/kg (2000mg/kg)		Drugs in Japan Vol. 6, Pg. 72, 1982.
rat	LD50	intraperitoneal	670mg/kg (670mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Oyo Yakuri. Pharmacometrics. Vol. 35, Pg. 287, 1988.
rat	LD50	intravenous	> 40mg/kg (40mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
rat	LD50	oral	747mg/kg (747mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 309, 1984.
rat	LD50	skin	> 3gm/kg (3000mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 35, Pg. 287, 1988.
rat	LD50	subcutaneous	1237mg/kg (1237mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 2109, 1982.
women	TDLo	oral	100ug/kg (0.1mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE CARDIAC: OTHER CHANGES	Southern Medical Journal. Vol. 84, Pg. 369, 1991.

supplier list

Varda Biotech Pvt. Ltd.: Tel:+91-(22)-6693 5686; Address: #110 & 111 Kartik Complex, New Link Road, Andheri (W), Mumbai, Maharashtra 400 053,

Facus Pharmaceutical Co., Ltd.: Tel:+86-(574)-6237-8411; Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800,

ZHONGBEI NORTHLAND BIO-CHEM INDUSTRY CO., LTD.: Tel:+86-452-6197139; Address: SONGLING DISTRICT, JIAGEDAQI CITY, DAXINGANLING, HEILONGJIANG PROVINCE, CHINA

Dottikon Exclusive Synthesis: Tel:41-56-6168111; Address: P.O. Box, 5605 Dottikon, Switzerland

Hubei Research Institute of Chemistry: Tel:+86-27-87422225; Address: No.30 Guanshan Road, Wuhan, Hubei, P. R. China

HangZhou Peak Chemical Co.,Ltd: Tel:+86-571-88233073; Address: Rm. 3-502,Building 3 Tucuiyuan,Lakeside Garden,No.176 Wenyi West Road, HangZhou,China

Wujiang Yingchuang Chemical Co., Ltd.: Tel:+86-(25)-8645 8768; Address: 215 Ying Tian Da Street, JianYe, Nanjing, Jiangsu 210017,

Shanghai Hope Chem Co., Ltd.: Tel:86-21-61723543; Address: Room508, Building1, No.88 CaiLun Road Zhangjiang H

shijiazhuang guizheng trade co.,ltd: Tel:86-312-18103315327; Address: east huaxia road pudong shanghai china

Nanjing Bangnuo Biotechnology Co., Ltd: Tel:86-1732-7098554; Address: shuanglong road,jiangning, nanjing,jiangsu

HEBEI CUI FENG IMPORT&EXPORT TRADE CO.,LTD: Tel:86-311-80955068; Address: No 98 Gongnong Street,Shijiazhuang Hebei,China

Ningbo Dekang biochem Co.,ltd: Tel:86-574-81657808; Address: room901 aolisai mansion, no 958 qianhu north road,ningbo

Shenyang Ideal Chemical Product Co.,Ltd: Tel:86-24-31689845; Address: :(1-7-4),18-A South No. 2 Road ,Heping District,

Boc Sciences: Tel:1-631-5046093; Address: 45-16 Ramsey Road Shirley, NY 11967, USA

Andexin industrial Co.,Limited: Tel:86-411-39074598; Address: No.98,Shengli road,,Jinzhou district,

isosorbide dinitrate cas no:87-33-2

Directory

supplier list