87-33-2|isosorbide dinitrateProducts Supply - Chemical intermediates Network

isosorbide dinitrate cas no:87-33-2

Synonyms: 1,4:3,6-dianhydrosorbitol 2,5-dinitrate; sorbide nitrate; Isosobide dinitrate

Identification

Nameisosorbide dinitrate
CAS87-33-2
Synonyms1,4:3,6-dianhydrosorbitol 2,5-dinitrate; sorbide nitrate; Isosobide dinitrate
EINECS(EC#)201-740-9
Molecular FormulaC6H8N2O8
Molecular Weight236.14

Chemical Properties

Appearancewhite crystalline powder
refractive index1.537
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass1.1A

Safety Data

Hazard Xn:Harmful;
Risk R5;R22
Safety

Moderately toxic by ingestion, intraperitoneal, intramuscular, and subcutaneous routes. Experimental reproductive effects. Mutation data reported. A flammable solid. When heated to decomposition it emits toxic fumes of NO_x. A coronary vasodilator.
Hazard Codes: Harmful Xn
Risk Statements: 5-22
R5 :Heating may cause an explosion.
R22:Harmful if swallowed.
Safety Statements: 36
S36:Wear suitable protective clothing.
RIDADR: UN 2907
HazardClass: 1.1A
PackingGroup: II

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	unreported	1109mg/kg (1109mg/kg)		French Demande Patent Document. Vol. #2454807,
man	TDLo	oral	1714ug/kg/3D- (1.714mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Australian and New Zealand Journal of Medicine. Vol. 27, Pg. 596, 1997.
mouse	LD50	intramuscular	1080mg/kg (1080mg/kg)		Drugs in Japan Vol. 6, Pg. 72, 1982.
mouse	LD50	intraperitoneal	720mg/kg (720mg/kg)		Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973.
mouse	LD50	intravenous	> 40mg/kg (40mg/kg)	BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
mouse	LD50	oral	1050mg/kg (1050mg/kg)		Drugs in Japan Vol. 6, Pg. 72, 1982.
mouse	LD50	subcutaneous	1050mg/kg (1050mg/kg)		Drugs in Japan Vol. 6, Pg. 72, 1982.
rabbit	LD50	intravenous	> 40mg/kg (40mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
rat	LD50	intramuscular	> 2gm/kg (2000mg/kg)		Drugs in Japan Vol. 6, Pg. 72, 1982.
rat	LD50	intraperitoneal	670mg/kg (670mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Oyo Yakuri. Pharmacometrics. Vol. 35, Pg. 287, 1988.
rat	LD50	intravenous	> 40mg/kg (40mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
rat	LD50	oral	747mg/kg (747mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 309, 1984.
rat	LD50	skin	> 3gm/kg (3000mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 35, Pg. 287, 1988.
rat	LD50	subcutaneous	1237mg/kg (1237mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 2109, 1982.
women	TDLo	oral	100ug/kg (0.1mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE CARDIAC: OTHER CHANGES	Southern Medical Journal. Vol. 84, Pg. 369, 1991.

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isosorbide dinitrate cas no:87-33-2

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