88069-49-2|Pilsicainide hydrochlorideProducts Supply

Pilsicainide hydrochloride cas no:88069-49-2

Synonyms: 1H-Pyrrolizine-7a(5H)-acetamide,N-(2,6-dimethylphenyl)tetrahydro-, monohydrochloride (9CI);Pilsicainidehydrochloride;Alisrythm;Sunrythm;Pilsicainide Hydrochloride and intermediates;Pilsicainidehydrochloride(forresearchonly);pilsicaininide;n-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide hydrochloride;

Identification

NamePilsicainide hydrochloride
CAS88069-49-2
Synonyms1H-Pyrrolizine-7a(5H)-acetamide,N-(2,6-dimethylphenyl)tetrahydro-, monohydrochloride (9CI);Pilsicainidehydrochloride;Alisrythm;Sunrythm;Pilsicainide Hydrochloride and intermediates;Pilsicainidehydrochloride(forresearchonly);pilsicaininide;n-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide hydrochloride;
Molecular FormulaC₁₇H₂₄N₂O.HCl
Molecular Weight308.85

Safety Data

Safety

Safety of Pilsicainide hydrochloride (CAS NO.88069-49-2): A poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits toxic vapors of NO_x, HCl, and Cl⁻.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	18mg/kg (18mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 461, 1991.
dog	LD50	oral	50mg/kg (50mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1398, 1988.
mouse	LD50	intraperitoneal	85mg/kg (85mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
mouse	LD50	intravenous	17mg/kg (17mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
mouse	LD50	oral	175mg/kg (175mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
mouse	LD50	subcutaneous	410mg/kg (410mg/kg)		Journal of Medicinal Chemistry. Vol. 28, Pg. 714, 1985.
rabbit	LD50	oral	87mg/kg (87mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1398, 1988.
rat	LD50	intraperitoneal	105mg/kg (105mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
rat	LD50	intravenous	18mg/kg (18mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
rat	LD50	oral	255mg/kg (255mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.

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Pilsicainide hydrochloride cas no:88069-49-2

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