2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)- cas no:88321-09-9
Synonyms: Oxiranecarboxylicacid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)- (9CI); Oxiranecarboxylic acid,3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethylester, [2S-[2a,3b(R*)]]-; Aloxistatin; E 64c ethylester; E 64d; EP 453; EST; EST (pharmaceutical); Loxistatin; NSC 694281
Name2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)-
CAS88321-09-9
SynonymsOxiranecarboxylicacid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)- (9CI); Oxiranecarboxylic acid,3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethylester, [2S-[2a,3b(R*)]]-; Aloxistatin; E 64c ethylester; E 64d; EP 453; EST; EST (pharmaceutical); Loxistatin; NSC 694281
Molecular FormulaC17H30 N2 O5
Molecular Weight342.49
refractive index1.485
storage temp−20°C
Hazard Xi: Irritant;
Risk R36/37/38
Safety
Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.Safety information of EST (CAS NO.88321-09-9):
Hazard Codes 
Xi
Risk Statements
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
WGK Germany 2
RTECS RR0404300
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
3270mg/kg (3270mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. |
| mouse |
LD50 |
oral |
> 10gm/kg (10000mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. |
| mouse |
LD50 |
subcutaneous |
> 7gm/kg (7000mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. |
| rat |
LD50 |
intraperitoneal |
2050mg/kg (2050mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. |
| rat |
LD50 |
oral |
> 10gm/kg (10000mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. |
| rat |
LD50 |
subcutaneous |
> 5gm/kg (5000mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986. |
