89-57-6|5-Aminosalicylic acidProducts Supply - Chemical intermediates Network

5-Aminosalicylic acid cas no:89-57-6

Synonyms: 5-Amino-2-hydroxybenzoic acid; Mesalamine; 5-ASA; 5-Amino salicylic acidl; Mesalazine; Mesalmine; mesalazine; 5-Amino salicylic Acid

Identification

Name5-Aminosalicylic acid
CAS89-57-6
Synonyms5-Amino-2-hydroxybenzoic acid; Mesalamine; 5-ASA; 5-Amino salicylic acidl; Mesalazine; Mesalmine; mesalazine; 5-Amino salicylic Acid
EINECS(EC#)201-919-1
Molecular FormulaC7H7NO3
Molecular Weight153.14

Chemical Properties

AppearanceWhite to off-white powder
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

HazardclassIRRITANT

Safety Data

Hazard Xi
Risk 36/37/38
Safety

Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: hypermotility, diarrhea, dermatitis, increased body temperature. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information of 5-Aminosalicylic acid (CAS NO.89-57-6).
Hazard Codes:? Irritant Xi
Risk Statements: 36/37/38?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.?
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: VO1400000
F: 8-10-23
Hazard Note: Irritant
HS Code: 29225000

HS Code 29225000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	51mg/kg/5D-I (51mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Lancet. Vol. 1, Pg. 917, 1984.
man	TDLo	oral	321mg/kg/15D- (321mg/kg)	SKIN AND APPENDAGES (SKIN): PHOTOSENSITIVITY: AFTER SYSTEMIC EXPOSURE	American Journal of Gastroenterology. Vol. 94, Pg. 3386, 1999.
man	TDLo	oral	2057mg/kg/17W (2057mg/kg)	BLOOD: AGRANULOCYTOSIS	Lancet. Vol. 341, Pg. 1476, 1993.
man	TDLo	oral	6857mg/kg/17W (6857mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "JAUNDICE, CHOLESTATIC"	Journal of Hepathology. Vol. 26, Pg. 425, 1997.
monkey	LDLo	oral	3gm/kg (3000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: HEMATURIA	Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 509, 1994.
mouse	LD50	intraperitoneal	469mg/kg (469mg/kg)	?	Archiv der Pharmazie Vol. 332, Pg. 321, 1999.
mouse	LD50	oral	3370mg/kg (3370mg/kg)	?	Archiv der Pharmazie Vol. 332, Pg. 321, 1999.
rabbit	LD50	skin	> 5gm/kg (5000mg/kg)	?	National Technical Information Service. Vol. OTS0570511,
rat	LD50	intraperitoneal	1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 505, 1994.
rat	LD50	oral	2800mg/kg (2800mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: OTHER CHANGES	National Technical Information Service. Vol. OTS0570511,
women	TDLo	oral	8mg/kg (8mg/kg)	BEHAVIORAL: HEADACHE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Lancet. Vol. 1, Pg. 917, 1984.
women	TDLo	oral	80mg/kg/1D-I (80mg/kg)	CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	American Journal of Gastroenterology. Vol. 93, Pg. 470, 1998.
women	TDLo	oral	5400mg/kg/90D (5400mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS	American Journal of Gastroenterology. Vol. 92, Pg. 2302, 1997.
women	TDLo	oral	8760mg/kg/1Y- (8760mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN BEHAVIORAL: MUSCLE WEAKNESS KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Clinical Nephrology. Vol. 49, Pg. 265, 1998.
women	TDLo	oral	21800mg/kg/39 (21800mg/kg)	LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BLOOD: EOSINOPHILIA	American Journal of Gastroenterology. Vol. 91, Pg. 1039, 1996.

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5-Aminosalicylic acid cas no:89-57-6

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