man |
TDLo |
oral |
51mg/kg/5D-I (51mg/kg) |
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Lancet. Vol. 1, Pg. 917, 1984. |
man |
TDLo |
oral |
321mg/kg/15D- (321mg/kg) |
SKIN AND APPENDAGES (SKIN): PHOTOSENSITIVITY: AFTER SYSTEMIC EXPOSURE |
American Journal of Gastroenterology. Vol. 94, Pg. 3386, 1999. |
man |
TDLo |
oral |
2057mg/kg/17W (2057mg/kg) |
BLOOD: AGRANULOCYTOSIS |
Lancet. Vol. 341, Pg. 1476, 1993. |
man |
TDLo |
oral |
6857mg/kg/17W (6857mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
LIVER: "JAUNDICE, CHOLESTATIC" |
Journal of Hepathology. Vol. 26, Pg. 425, 1997. |
monkey |
LDLo |
oral |
3gm/kg (3000mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
KIDNEY, URETER, AND BLADDER: HEMATURIA |
Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 509, 1994. |
mouse |
LD50 |
intraperitoneal |
469mg/kg (469mg/kg) |
? |
Archiv der Pharmazie Vol. 332, Pg. 321, 1999. |
mouse |
LD50 |
oral |
3370mg/kg (3370mg/kg) |
? |
Archiv der Pharmazie Vol. 332, Pg. 321, 1999. |
rabbit |
LD50 |
skin |
> 5gm/kg (5000mg/kg) |
? |
National Technical Information Service. Vol. OTS0570511, |
rat |
LD50 |
intraperitoneal |
1gm/kg (1000mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION |
Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 505, 1994. |
rat |
LD50 |
oral |
2800mg/kg (2800mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: FOOD INTAKE (ANIMAL)
GASTROINTESTINAL: OTHER CHANGES |
National Technical Information Service. Vol. OTS0570511, |
women |
TDLo |
oral |
8mg/kg (8mg/kg) |
BEHAVIORAL: HEADACHE
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Lancet. Vol. 1, Pg. 917, 1984. |
women |
TDLo |
oral |
80mg/kg/1D-I (80mg/kg) |
CARDIAC: PULSE RATE
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
American Journal of Gastroenterology. Vol. 93, Pg. 470, 1998. |
women |
TDLo |
oral |
5400mg/kg/90D (5400mg/kg) |
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS |
American Journal of Gastroenterology. Vol. 92, Pg. 2302, 1997. |
women |
TDLo |
oral |
8760mg/kg/1Y- (8760mg/kg) |
BEHAVIORAL: ANOREXIA (HUMAN
BEHAVIORAL: MUSCLE WEAKNESS
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
Clinical Nephrology. Vol. 49, Pg. 265, 1998. |
women |
TDLo |
oral |
21800mg/kg/39 (21800mg/kg) |
LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BLOOD: EOSINOPHILIA |
American Journal of Gastroenterology. Vol. 91, Pg. 1039, 1996. |